{"doi":"10.4049/jimmunol.100.3.586","title":"Heterogeneity in the Properties of 7 S and 19 S Rabbit-Neutralizing Antibodies to Herpes Simplex Virus","abstract":"<jats:title>Summary</jats:title>\n               <jats:p>The 7 S and 19 S rabbit antibodies to herpes simplex virus (HSV) from early and late (hyperimmune) sera differed in their ability to sensitize virus for subsequent neutralization by either complement (C′) or anti-γ-globulin (GAR).</jats:p>\n               <jats:p>The early 7 S and 19 S antibodies showed low to negligible neutralizing activity in the absence of C′ or GAR. When C′ was added, however, both of these antibodies showed enhanced neutralizing activity. The early 7 S but not the early 19 S antibody was also capable of sensitizing virus for subsequent neutralization by GAR.</jats:p>\n               <jats:p>The late 19 S antibody could neutralize virus in the absence of C′ or GAR, but its activity was enhanced in the presence of C′ or GAR. The late 7 S antibody showed high neutralizing activity in the absence of C′ or GAR. In the presence of C′, the neutralization rate constants (K) but not the neutralization titers of the late 7 S antibody were enhanced. In contrast, the neutralization titers of the late 7 S antibody were enhanced approximately threefold with GAR.</jats:p>\n               <jats:p>The neutralizing activity of the early and late 19 S antibodies with C′ or GAR was sensitive to inactivation by 2-ME. Similarly, the neutralizing activity with C′ of the early 7 S antibody and the enhanced rate of neutralization with C′ of the late 7 S antibody were sensitive to inactivation by 2-ME. In contrast, 2-ME did not reduce the neutralization titers of the early and late 7 S antibodies in the presence of GAR.</jats:p>","journal":"The Journal of Immunology","year":1968,"id":21442,"datarank":7.78563489690093,"base_score":4.624972813284271,"endowment":4.624972813284271,"self_citation_contribution":0.6937459219926407,"citation_network_contribution":7.091888974908289,"self_endowment_contribution":0.6937459219926407,"citer_contribution":7.091888974908289,"corpus_percentile":null,"corpus_rank":null,"citation_count":101,"citer_count":77,"citers_with_citation_signal":71,"citers_with_endowment":71,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":138061,"name":"A L Notkins","orcid":null,"position":1,"is_corresponding":false},{"id":138062,"name":"M Mage","orcid":null,"position":2,"is_corresponding":false},{"id":138063,"name":"M A Keehn","orcid":null,"position":3,"is_corresponding":false},{"id":138059,"name":"B Hampar","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.624972813284271,"endowment":4.624972813284271,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"4296105","pmcid":null,"openalex_id":"https://openalex.org/W1545923077","authors":[],"funders":[],"total_grants":0,"fwci":12.9838,"citation_percentile":0.98694543,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://academic.oup.com/pages/standard-publication-reuse-rights","oa_locations":[{"url":"https://journals.aai.org/jimmunol/article-pdf/100/3/586/986119/ji1000030586.pdf","host_type":"BRONZE"},{"url":"https://academic.oup.com/jimmunol/article-pdf/100/3/586/62498722/ji1000030586.pdf","host_type":"publisher"},{"url":"https://doi.org/10.4049/jimmunol.100.3.586","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/4296105","host_type":"repository"}],"fields_of_study":["Herpesvirus Infections and Treatments","Animal Virus Infections Studies","Virus-based gene therapy research","Biology","Medicine"],"mesh_terms":["Animals","Antibodies, Anti-Idiotypic","Antibody Formation","Complement System Proteins","Immunoglobulin G","Immunoglobulin M","Immune Sera","Neutralization Tests","Rabbits","Time Factors","Simplexvirus"],"keywords":["Neutralization","Antibody","Neutralizing antibody","Herpes simplex virus","Virology","Titer","Virus","Biology","Chemistry","Immunology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-06T15:57:26.357599Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}