{"doi":"10.4049/immunohorizons.2400002","title":"IL-10 Neutralization Attenuates Mast Cell Responses in a Murine Model of Experimental Food Allergy","abstract":"IgE-mediated mast cell (MC) activation is a critical component of allergic responses to oral Ags. Several T cell-derived cytokines have been shown to promote MC reactivity, and we recently demonstrated a critical role for the cytokine IL-10 in mediating MC responses during food allergy. In this study, we further validate the role of IL-10 using Ab-mediated IL-10 depletion. IL-10 neutralization significantly attenuated MC responses, leading to decreased MC accumulation and activation, as well as inhibition of MC-mediated symptoms such as allergic diarrhea. This was accompanied by decreased Th2 cytokine gene expression, attenuated systemic T cell responses, and fewer CD4 T cells, B cells, and MCs in the spleen. Our data further confirm the role of IL-10 in driving MC responses and suggest that IL-10-responsive MCs may constitute an important player in allergic responses.","journal":"ImmunoHorizons","year":2024,"id":468310,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1172280,"name":"Saurav Ranjitkar","orcid":null,"position":1,"is_corresponding":false},{"id":1294535,"name":"Caitlin Tedeschi","orcid":null,"position":2,"is_corresponding":false},{"id":1301454,"name":"Nicole Maldonado Perez","orcid":null,"position":3,"is_corresponding":false},{"id":1301455,"name":"Nathan Jordan","orcid":null,"position":4,"is_corresponding":false},{"id":693816,"name":"Mohamed Mire","orcid":"0000-0003-2468-5289","position":5,"is_corresponding":false},{"id":333509,"name":"Sallie S. Schneider","orcid":"0000-0003-0093-4308","position":6,"is_corresponding":false},{"id":411434,"name":"Clinton B. Mathias","orcid":"0000-0002-0223-4842","position":7,"is_corresponding":false},{"id":412603,"name":"Dylan Krajewski","orcid":null,"position":0,"is_corresponding":true}],"reference_count":75,"raw_metadata":null,"created_at":"2026-07-19T02:05:19.071498Z","pmid":"38888412","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}