{"doi":"10.4049/immunohorizons.2300108","title":"SARS-CoV-2 Vaccine-Elicited Immunity after B Cell Depletion in Multiple Sclerosis","abstract":"The impact of B cell deficiency on the humoral and cellular responses to SARS-CoV2 mRNA vaccination remains a challenging and significant clinical management question. We evaluated vaccine-elicited serological and cellular responses in 1) healthy individuals who were pre-exposed to SARS-CoV-2 (n = 21), 2) healthy individuals who received a homologous booster (mRNA, n = 19; or Novavax, n = 19), and 3) persons with multiple sclerosis on B cell depletion therapy (MS-αCD20) receiving mRNA homologous boosting (n = 36). Pre-exposure increased humoral and CD4 T cellular responses in immunocompetent individuals. Novavax homologous boosting induced a significantly more robust serological response than mRNA boosting. MS-α CD20 had an intact IgA mucosal response and an enhanced CD8 T cell response to mRNA boosting compared with immunocompetent individuals. This enhanced cellular response was characterized by the expansion of only effector, not memory, T cells. The enhancement of CD8 T cells in the setting of B cell depletion suggests a regulatory mechanism between B and CD8 T cell vaccine responses.","journal":"ImmunoHorizons","year":2024,"id":476476,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9622,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1069695,"name":"Berenice Cabrera-Martinez","orcid":"0009-0000-2919-2729","position":1,"is_corresponding":false},{"id":495662,"name":"Tusharkanti Ghosh","orcid":"0000-0002-7537-6374","position":2,"is_corresponding":false},{"id":1142074,"name":"Cody Rester","orcid":"0000-0002-0452-2223","position":3,"is_corresponding":false},{"id":1314014,"name":"Miguel Guerrero Moreno","orcid":"0009-0000-5308-0428","position":4,"is_corresponding":false},{"id":1013122,"name":"Tyler L. 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