{"doi":"10.4049/immunohorizons.2300038","title":"MAVS Positively Regulates Mitochondrial Integrity and Metabolic Fitness in B Cells","abstract":"Activated B cells experience metabolic changes that require mitochondrial remodeling, in a process incompletely defined. In this study, we report that mitochondrial antiviral signaling protein (MAVS) is involved in BCR-initiated cellular proliferation and prolonged survival. MAVS is well known as a mitochondrial-tethered signaling adaptor with a central role in viral RNA-sensing pathways that induce type I IFN. The role of MAVS downstream of BCR stimulation was recognized in absence of IFN, indicative of a path for MAVS activation that is independent of viral infection. Mitochondria of BCR-activated MAVS-deficient mouse B cells exhibited a damaged phenotype including disrupted mitochondrial morphology, excess mitophagy, and the temporal progressive blunting of mitochondrial oxidative capacity with mitochondrial hyperpolarization and cell death. Costimulation of MAVS-deficient B cells with anti-CD40, in addition to BCR stimulation, partially corrected the mitochondrial structural defects and functionality. Our data reveal a (to our knowledge) previously unrecognized role of MAVS in controlling the metabolic fitness of B cells, most noticeable in the absence of costimulatory help.","journal":"ImmunoHorizons","year":2023,"id":368182,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":457992,"name":"Wenxiang Sun","orcid":null,"position":1,"is_corresponding":false},{"id":513495,"name":"Javier Traba","orcid":"0000-0002-7855-3540","position":2,"is_corresponding":false},{"id":747540,"name":"Juan Wu","orcid":"0000-0002-2660-0587","position":3,"is_corresponding":false},{"id":324947,"name":"Chen‐Feng Qi","orcid":null,"position":4,"is_corresponding":false},{"id":747969,"name":"Laura Amo","orcid":null,"position":5,"is_corresponding":false},{"id":747970,"name":"Hemanta K. Kole","orcid":null,"position":6,"is_corresponding":false},{"id":747971,"name":"Bethany Scott","orcid":null,"position":7,"is_corresponding":false},{"id":268700,"name":"Komudi Singh","orcid":"0000-0002-6413-541X","position":8,"is_corresponding":false},{"id":329922,"name":"Michael N. Sack","orcid":"0000-0002-3411-0000","position":9,"is_corresponding":false},{"id":456732,"name":"Silvia Bolland","orcid":"0000-0002-9662-2394","position":10,"is_corresponding":false},{"id":1092427,"name":"Hongsheng Wang","orcid":"0000-0003-0079-0236","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T01:15:20.453499Z","pmid":"37610299","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}