{"doi":"10.4049/immunohorizons.2300001","title":"Jagged-1 Reduces Th2 Inflammation and Memory Cell Expansion in Allergic Airway Disease","abstract":"Notch ligands present during interactions between T cells and dendritic cells (DCs) dictate cell phenotype through a myriad of effects including the induction of T cell regulation, survival, and cytokine response. The presence of Notch ligands on DCs varies with the context of the inflammatory response; Jagged-1 is constitutively expressed, whereas Delta-like 1 and Delta-like 4 are induced in response to pathogen exposure. Although Delta-like and Jagged ligands send different signals through the same Notch receptor, the role of these two ligands in peripheral T cell immunity is not clear. The goal of our studies was to determine the role of Jagged-1 in the pathogen-free inflammation induced by OVA during allergic airway disease in mice. Our studies show that a deletion in DC-expressed Jagged-1 causes a significant increase in cytokine production, resulting in increased mucus production and increased eosinophilia in the lungs of mice sensitized and challenged with OVA. We also observed that a reduction of Jagged-1 expression is correlated with increased expression of the Notch 1 receptor on the surface of CD4+ T cells in both the lung and lymph node. Through transfer studies using OT-II transgenic T cells, we demonstrate that Jagged-1 represses the expansion of CD44+CD62L+CCR7+ memory cells and promotes the expansion of CD44+CD62L- effector cells, but it has no effect on the expansion of naive cells during allergic airway disease. These data suggest that Jagged-1 may have different roles in Ag-specific T cell responses, depending on the maturity of the stimulated T cell.","journal":"ImmunoHorizons","year":2023,"id":387802,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9413,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":661570,"name":"Zadia Dupee","orcid":"0000-0003-2928-4249","position":1,"is_corresponding":false},{"id":1156849,"name":"Felipe Gallego Lima","orcid":"0000-0003-1204-5743","position":2,"is_corresponding":false},{"id":350127,"name":"Ronald M. Allen","orcid":"0000-0002-9542-5874","position":3,"is_corresponding":false},{"id":1156850,"name":"Soha Kazmi","orcid":"0000-0003-3643-8031","position":4,"is_corresponding":false},{"id":1095287,"name":"Nickolas Diodati","orcid":"0000-0002-2151-8090","position":5,"is_corresponding":false},{"id":289672,"name":"Nicholas W. Lukacs","orcid":"0000-0003-2403-6481","position":6,"is_corresponding":false},{"id":295113,"name":"Steven L. Kunkel","orcid":"0000-0002-5738-6341","position":7,"is_corresponding":false},{"id":400669,"name":"Matthew Schaller","orcid":"0000-0003-3338-0655","position":8,"is_corresponding":false},{"id":1156848,"name":"Soichiro Kimura","orcid":"0000-0003-4278-1741","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T01:18:08.845494Z","pmid":"36729482","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}