{"doi":"10.3906/sag-1911-16","title":"Peripheral blood soluble elastin and elastase as auxiliary diagnostic indicators for coronary artery ectasia","abstract":null,"journal":"TURKISH JOURNAL OF MEDICAL SCIENCES","year":2021,"id":622603,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1608729,"name":"Qianqian SHENG","orcid":"0000-0002-2296-3911","position":1,"is_corresponding":false},{"id":1392845,"name":"Siwen Liang","orcid":"0000-0002-4421-7485","position":2,"is_corresponding":false},{"id":1608730,"name":"Huiqiang ZHAO","orcid":"0000-0002-7175-8703","position":3,"is_corresponding":false},{"id":1608728,"name":"Ruifeng LIU","orcid":"0000-0003-2405-5447","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Peripheral blood soluble elastin and elastase as auxiliary diagnostic indicators for coronary artery ectasia","abstract":"Background/aim: Damage to elastin fibres in coronary media might lead to coronary artery ectasia (CAE). This study evaluated whether CAE can be distinguished by detecting circulating soluble elastin (s-elastin), which is a degradation product of elastin fibres, and elastase, which is the main enzyme of elastin fibres. Materials and methods: Fifty-eight patients with CAE, 58 with coronary heart disease (CHD) and 61 with relatively normal coronary arteries, were included. Circulating s-elastin and elastase were measured, and receiver operating characteristic curves were used to demonstrate their respective optimal cut-off values for predicting CAE. Results: The concentrations of s-elastin and elastase were higher in the CAE group than in the CHD and relatively-normal-coronary groups. Their cut-off values for screening of CAE were 13.148 ng/mL and 25.549 ng/mL, respectively; for sensitivity of CAE were 0.690 and 0.773, respectively; and for specificity of CAE were 0.862 and 0.571, respectively. A combination of s-elastin and elastase in series (one of the two higher than its cut-off value) had a better sensitivity for screening for CAE, whereas their combination in parallel (both higher than their cut-off values) had a better specificity. Conclusion: Circulating s-elastin and elastase are promising biomarkers for assisting in CAE diagnosis.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33315345","pmcid":"PMC8283459","openalex_id":"https://openalex.org/W3113946390","authors":[],"funders":[],"total_grants":0,"fwci":0.3916,"citation_percentile":0.63822164,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.3906/sag-1911-16","host_type":"journal"},{"url":"https://doi.org/10.3906/sag-1911-16","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33315345","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8283459","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8283459","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8283459?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Kawasaki Disease and Coronary Complications","Coronary Interventions and Diagnostics","Cardiovascular Issues in Pregnancy","Coronary Angiography","Coronary Artery Disease","Dilatation, Pathologic","Elastin","Humans","Pancreatic Elastase"],"mesh_terms":["Coronary Artery Disease","Dilatation, Pathologic","Elastin","Humans","Pancreatic Elastase","Coronary Angiography"],"keywords":["Elastin","Coronary artery ectasia","Elastase","Medicine","Internal medicine","Cardiology","Ectasia","Coronary arteries","Artery","Pathology","Coronary angiography","Enzyme","Biochemistry","Chemistry","Biomarker","Soluble Elastin"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T20:16:57.581324Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}