{"doi":"10.3899/jrheum.200863","title":"Lifestyle and Clinical Risk Factors for Incident Rheumatoid Arthritis-associated Interstitial Lung Disease","abstract":"OBJECTIVE: To determine the association between novel lifestyle factors on risk of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD), define the threshold at which smoking increases RA-ILD risk, and calculate the degree to which known lifestyle and clinical factors predict RA-ILD. METHODS: This nested case-control study matched incident RA-ILD cases to RA non-ILD controls on age, sex, RA duration, rheumatoid factor, and time from exposure assessment to RA-ILD. Exposures included education, BMI, smoking, anticyclic citrullinated peptide antibodies, race, joint erosions, rheumatoid nodules, C-reactive protein (CRP), disease activity score, functional status, disease-modifying antirheumatic drug use, and glucocorticoid use. OR for each exposure on risk of RA-ILD were obtained from logistic regression models. Area under the curve (AUC) was calculated based on all lifestyle and clinical exposures. RESULTS: We identified 84 incident RA-ILD cases and 233 matched controls. After adjustment, obesity, high-positive CRP (≥ 10 mg/L), and poor functional status (multidimensional Health Assessment Questionnaire [MDHAQ] ≥ 1) were associated with increased risk of RA-ILD (OR 2.42, 95% CI 1.11-5.24 vs normal BMI; OR 2.61, 95% CI 1.21-5.64 vs CRP < 3 mg/L; OR 3.10, 95% CI 1.32-7.26 vs MDHAQ < 0.2). Smoking 30 pack-years or more was strongly associated with risk of RA-ILD compared to never smokers (OR 6.06, 95% CI 2.72-13.5). Together, lifestyle and clinical risk factors for RA-ILD had an AUC of 0.79 (95% CI 0.73-0.85). CONCLUSION: Obesity, CRP, functional status, and extensive smoking may be novel risk factors for RA-ILD that may be useful for RA-ILD risk assessment and prevention. The overall ability to predict RA-ILD remains modest.","journal":"The Journal of Rheumatology","year":2020,"id":53882,"datarank":3.3077885095804103,"base_score":4.74493212836325,"endowment":4.74493212836325,"self_citation_contribution":0.7117398192544876,"citation_network_contribution":2.596048690325923,"self_endowment_contribution":0.7117398192544876,"citer_contribution":2.596048690325923,"corpus_percentile":null,"corpus_rank":null,"citation_count":114,"citer_count":97,"citers_with_citation_signal":71,"citers_with_endowment":71,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9469,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":275604,"name":"Weixing Huang","orcid":"0009-0009-5279-394X","position":1,"is_corresponding":false},{"id":275605,"name":"Paul F. Dellaripa","orcid":"0000-0003-0237-739X","position":2,"is_corresponding":false},{"id":275606,"name":"Sicong Huang","orcid":"0000-0003-0854-4734","position":3,"is_corresponding":false},{"id":275607,"name":"Vivi Feathers","orcid":"0000-0002-7112-3767","position":4,"is_corresponding":false},{"id":275608,"name":"Bing Lü","orcid":"0000-0002-0031-5999","position":5,"is_corresponding":false},{"id":276682,"name":"Christine Iannaccone","orcid":null,"position":6,"is_corresponding":false},{"id":275609,"name":"Ritu R. Gill","orcid":"0000-0001-8119-8407","position":7,"is_corresponding":false},{"id":253857,"name":"Hiroto Hatabu","orcid":"0000-0003-1436-2988","position":8,"is_corresponding":false},{"id":243071,"name":"Mizuki Nishino","orcid":"0000-0003-0275-0502","position":9,"is_corresponding":false},{"id":275610,"name":"Cynthia S. Crowson","orcid":"0000-0001-5847-7475","position":10,"is_corresponding":false},{"id":275611,"name":"John M. Davis","orcid":"0000-0002-9710-8143","position":11,"is_corresponding":false},{"id":27561,"name":"Michael E. Weinblatt","orcid":"0000-0001-5215-5512","position":12,"is_corresponding":false},{"id":27560,"name":"Nancy A. Shadick","orcid":"0000-0003-3953-845X","position":13,"is_corresponding":false},{"id":275612,"name":"Tracy J. Doyle","orcid":"0000-0002-0770-1059","position":14,"is_corresponding":false},{"id":236764,"name":"Jeffrey A. Sparks","orcid":"0000-0002-5556-4618","position":15,"is_corresponding":false},{"id":275603,"name":"Vanessa L. Kronzer","orcid":"0000-0002-7489-3134","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T20:45:25.145885Z","pmid":"33191286","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}