{"doi":"10.3892/or.7.4.875","title":"Comparison of 5-FU and leucovorin to gemcitabine in the treatment of pancreatic cancer.","abstract":null,"journal":"Oncology Reports","year":2000,"id":599419,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1536223,"name":"E Sadikov","orcid":null,"position":1,"is_corresponding":false},{"id":1536224,"name":"M Mishaeli","orcid":null,"position":2,"is_corresponding":false},{"id":1536225,"name":"I Levin","orcid":null,"position":3,"is_corresponding":false},{"id":1536226,"name":"A Figer","orcid":null,"position":4,"is_corresponding":false},{"id":1536222,"name":"B Klein","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Comparison of 5-FU and leucovorin to gemcitabine in the treatment of pancreatic cancer.","abstract":"Gemcitabine has been recently added to the 5-fluorouracil (5-FU) protocol in the treatment of both new and 5-FU refractory patients with pancreatic cancer. We compared the efficacy of gemcitabine versus 5-FU and leucovorin (LCV) in 82 patients with advanced pancreatic cancer. Forty-seven patients received 5-FU and LCV and 35 patients received gemcitabine. Objective responses were documented in 4% on the 5-FU and LCV arm, compared to 9% in the gemcitabine arm. No change was observed in 48% on the 5-FU and LCV arm compared to 20% in the gemcitabine arm. Clinical benefit was observed in 19% on the 5-FU and LCV arm compared to 48% in the gemcitabine arm (p<0. 001). Toxicity was mild and well tolerated in both arms. One-year survival was 32% on the 5-FU and LCV arm and 23% in the gemcitabine arm. These results indicate that gemcitabine had a significantly higher clinical benefit than 5-FU and should be the standard treatment in advanced pancreatic cancer.","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10854561","pmcid":null,"openalex_id":"https://openalex.org/W2001909134","authors":[],"funders":[],"total_grants":0,"fwci":0.6392,"citation_percentile":0.69227858,"influential_citations":0,"citation_trend":[{"year":2024,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://spandidos-publications.com/10.3892/or.7.4.875/download","host_type":"publisher"},{"url":"https://doi.org/10.3892/or.7.4.875","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10854561","host_type":"repository"}],"fields_of_study":["Pancreatic and Hepatic Oncology Research","Colorectal Cancer Treatments and Studies","Cancer Genomics and Diagnostics","Aged","Aged, 80 and over","Antimetabolites, Antineoplastic","Deoxycytidine","Disease-Free Survival","Fluorouracil","Humans","Leucovorin","Middle Aged","Neoplasm Staging","Pancreatic Neoplasms","Retrospective Studies","Survival Analysis","Gemcitabine"],"mesh_terms":["Gemcitabine","Aged","Aged, 80 and over","Antimetabolites, Antineoplastic","Leucovorin","Deoxycytidine","Fluorouracil","Humans","Middle Aged","Neoplasm Staging","Pancreatic Neoplasms","Retrospective Studies","Survival Analysis","Disease-Free Survival"],"keywords":["Gemcitabine","Pancreatic cancer","Medicine","Internal medicine","Antimetabolite","Oncology","Fluorouracil","Cancer","Gastroenterology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T04:21:35.716495Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}