{"doi":"10.3892/mmr.2024.13245","title":"Dual‑regulated oncolytic adenovirus carrying <i>ERCC1</i>‑siRNA gene possesses potent antitumor effect on ovarian cancer cells","abstract":null,"journal":"Molecular Medicine Reports","year":2024,"id":633679,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1472714,"name":"Wei Ye","orcid":"0000-0003-0360-7900","position":1,"is_corresponding":false},{"id":604716,"name":"Rui Zhang","orcid":"0000-0003-0310-6030","position":2,"is_corresponding":false},{"id":1224834,"name":"Xiaoyan Zhu","orcid":"0000-0001-9616-9289","position":3,"is_corresponding":false},{"id":1643065,"name":"Qin Shi","orcid":null,"position":4,"is_corresponding":false},{"id":845813,"name":"Xiaofeng Xu","orcid":"0000-0002-6553-6514","position":5,"is_corresponding":false},{"id":1204014,"name":"Weifeng Chen","orcid":"0000-0003-3655-3590","position":6,"is_corresponding":false},{"id":1155015,"name":"Ling Xu","orcid":"0000-0003-0798-2126","position":7,"is_corresponding":false},{"id":1575612,"name":"Yaping Meng","orcid":null,"position":8,"is_corresponding":false},{"id":989025,"name":"Ting Zhao","orcid":"0000-0002-8053-412X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Dual‑regulated oncolytic adenovirus carrying <i>ERCC1</i>‑siRNA gene possesses potent antitumor effect on ovarian cancer cells","abstract":"Ovarian cancer is a multifactorial and deadly disease. Despite significant advancements in ovarian cancer therapy, its incidence is on the rise and the molecular mechanisms underlying ovarian cancer invasiveness, metastasis and drug resistance remain largely elusive, resulting in poor prognosis. Oncolytic viruses armed with therapeutic transgenes of interest offer an attractive alternative to chemical drugs, which often face innate and acquired drug resistance. The present study constructed a novel oncolytic adenovirus carrying <em>ERCC1</em> short interfering (si)RNA, regulated by <em>hTERT</em> and <em>HIF</em> promoters, termed Ad‑siERCC1. The findings demonstrated that this oncolytic adenovirus effectively inhibits the proliferation, migration and invasion of ovarian cancer cells. Furthermore, the downregulation of <em>ERCC1</em> expression by siRNA ameliorates drug resistance to cisplatin (DDP) chemotherapy. It was found that Ad‑siERCC1 blocks the cell cycle in the G<sub>1</sub> phase and enhances apoptosis through the PI3K/AKT‑caspase‑3 signaling pathways in SKOV3 cells. The results of the present study highlighted the critical effect of oncolytic virus Ad‑siERCC1 in inhibiting the survival of ovarian cancer cells and increasing chemotherapy sensitivity to DDP. These findings underscore the potent antitumor effect of Ad‑siERCC1 on ovarian cancers <em>in vivo.</em>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38757346","pmcid":"PMC11129538","openalex_id":"https://openalex.org/W4396928617","authors":[],"funders":[],"total_grants":0,"fwci":2.3177,"citation_percentile":0.88106393,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":2},{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"http://www.spandidos-publications.com/10.3892/mmr.2024.13245/download","host_type":"journal"},{"url":"http://www.spandidos-publications.com/10.3892/mmr.2024.13245/download","host_type":"publisher"},{"url":"https://doi.org/10.3892/mmr.2024.13245","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38757346","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11129538","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11129538/pdf/mmr-30-01-13245.pdf","host_type":"repository"},{"url":"https://www.spandidos-publications.com/10.3892/mmr.2024.13245/download","host_type":"Unpaywall"},{"url":"https://europepmc.org/articles/PMC11129538","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11129538?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Virus-based gene therapy research","Viral Infectious Diseases and Gene Expression in Insects","Cancer Research and Treatments","Female","Humans","Adenoviridae","Antineoplastic Agents","Apoptosis","Cell Line, Tumor","Cell Movement","Cell Proliferation","Cisplatin","DNA-Binding Proteins","Drug Resistance, Neoplasm","Endonucleases","Genetic Vectors","Oncolytic Virotherapy","Oncolytic Viruses","Ovarian Neoplasms","Phosphatidylinositol 3-Kinases","Proto-Oncogene Proteins c-akt","RNA, Small Interfering","Signal Transduction"],"mesh_terms":["Adenoviridae","Antineoplastic Agents","Cell Movement","Cisplatin","DNA-Binding Proteins","Endonucleases","Female","Genetic Vectors","Humans","Ovarian Neoplasms","Signal Transduction","Apoptosis","Drug Resistance, Neoplasm","Phosphatidylinositol 3-Kinases","RNA, Small Interfering","Cell Line, Tumor","Cell Proliferation","Oncolytic Virotherapy","Oncolytic Viruses","Proto-Oncogene Proteins c-akt"],"keywords":["Oncogene","Cancer research","Oncolytic virus","Ovarian cancer","Biology","Cancer","Gene","Cell cycle","Oncolytic adenovirus","Molecular medicine","Transfection","Virology","Genetic enhancement","Tumor cells","Genetics","Proliferation","Adenovirus","ERCC1","Htert/hif"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T12:28:47.318875Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}