{"doi":"10.3892/mmr.2015.4670","title":"RBEL1 is required for osteosarcoma cell proliferation via inhibiting retinoblastoma 1","abstract":null,"journal":"Molecular Medicine Reports","year":2016,"id":657193,"datarank":1.3136325175320709,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"self_citation_contribution":0.5101796072493234,"citation_network_contribution":0.8034529102827475,"self_endowment_contribution":0.5101796072493234,"citer_contribution":0.8034529102827475,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":23,"citers_with_citation_signal":21,"citers_with_endowment":21,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1715553,"name":"FENG JI","orcid":null,"position":1,"is_corresponding":false},{"id":1715554,"name":"JIN SUN","orcid":null,"position":2,"is_corresponding":false},{"id":1715555,"name":"YUE XIE","orcid":null,"position":3,"is_corresponding":false},{"id":1715556,"name":"YONGYI XU","orcid":null,"position":4,"is_corresponding":false},{"id":1715557,"name":"HAITAO YUE","orcid":null,"position":5,"is_corresponding":false},{"id":1715552,"name":"HONGHUI TANG","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"RBEL1 is required for osteosarcoma cell proliferation via inhibiting retinoblastoma 1","abstract":"Osteosarcoma is the most common type of primary malignant tumor of the bone. However, mechanisms underlying osteosarcoma cell proliferation are poorly understood. The present study shows that RBEL1, a newly identified Rab-like GTPase, may be a key regulator of osteosarcoma cell proliferation. Knockdown of RBEL1 in osteosarcoma cells resulted in impaired colony formation and cell proliferation. Cell cycle analysis suggested that RBEL1 depletion induced G1-S arrest in osteosarcoma cells. Furthermore, it was demonstrated that retinoblastoma 1 (Rb) was upregulated and activated following RBEL1 knockdown. In addition, Rb inhibitory downstream targets, such as cyclin A2, cyclin D1, c-Myc and cyclin-dependent kinase 2, were downregulated. Rb knockdown reversed RBEL1 depletion-induced tumor suppressive effects. In conclusion, the present results suggest that RBEL1 modulates cell proliferation and G1‑S transition by inhibiting Rb in osteosarcoma. These results suggest a potential therapeutic target in osteosarcoma.","is_dataset_classified":null,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26676380","pmcid":null,"openalex_id":"https://openalex.org/W2192274534","authors":[],"funders":[],"total_grants":0,"fwci":0.6561,"citation_percentile":0.71152455,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2018,"count":4},{"year":2019,"count":1},{"year":2020,"count":10},{"year":2021,"count":6},{"year":2022,"count":2},{"year":2023,"count":3},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"http://www.spandidos-publications.com/10.3892/mmr.2015.4670/download","host_type":"journal"},{"url":"http://www.spandidos-publications.com/10.3892/mmr.2015.4670/download","host_type":"publisher"},{"url":"https://spandidos-publications.com/10.3892/mmr.2015.4670/download","host_type":"publisher"},{"url":"https://doi.org/10.3892/mmr.2015.4670","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26676380","host_type":"repository"}],"fields_of_study":["Cancer-related Molecular Pathways","Microtubule and mitosis dynamics","Cell death mechanisms and regulation"],"mesh_terms":["Humans","Phosphorylation","Osteosarcoma","Retinoblastoma Protein","Proto-Oncogene Proteins c-myc","ras Proteins","Cyclin D1","Cell Line, Tumor","Cell Proliferation","Cyclin-Dependent Kinase 2","Gene Knockdown Techniques","Cyclin A2"],"keywords":["Osteosarcoma","Cell cycle","Cancer research","Cyclin D1","Cell growth","Retinoblastoma protein","Gene knockdown","Retinoblastoma","Oncogene","Biology","Cell cycle checkpoint","Cell","Apoptosis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T00:08:44.834192Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}