{"doi":"10.3823/846","title":"Antimicrobial Resistance and Biofilm Formation of Pseudomonas aeruginosa","abstract":"<jats:p>Abstract\r\nPseudomonas aeruginosa threatens patient’s care. It is considered as the most complicated health care associated pathogen to be eliminated from infection site. The biofilm forming ability of P. aeruginosa, being a major virulence factor for most pathogenic microorganism, protects it from host immunity and contribute to antibiotic resistance of this organism. It is estimated that about 80% of infectious diseases are due to biofilm mode of growth. Biofilm forming ability of bacteria imparts antimicrobial resistance that leads to many persistent and chronic bacterial infections. The world is becoming increasingly under the threat of entering the “post-antibiotic era”, an era in which the rate of death from bacterial infections is higher than from cancer.\r\nThis review focus on P. aeruginosa biofilm forming ability; definition, developmental stages, and significance. In addition, the quorum sensing and the antibiotic resistance of this pathogen is discussed.\r\nKeywords: Biofilm; bacterial adhesion; Pseudomonas aeruginosa; antimicrobial resistance; quorum sensing.</jats:p>","journal":"The International Arabic Journal of Antimicrobial Agents","year":2020,"id":682097,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1782002,"name":"Suhaila Al-Sheboul","orcid":null,"position":1,"is_corresponding":false},{"id":1782003,"name":"Renad I Abu-Dan","orcid":null,"position":2,"is_corresponding":false},{"id":1782001,"name":"Abdelraouf A Elmanama","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Antimicrobial Resistance and Biofilm Formation of Pseudomonas aeruginosa","abstract":"<jats:p>Abstract\r\nPseudomonas aeruginosa threatens patient’s care. It is considered as the most complicated health care associated pathogen to be eliminated from infection site. The biofilm forming ability of P. aeruginosa, being a major virulence factor for most pathogenic microorganism, protects it from host immunity and contribute to antibiotic resistance of this organism. It is estimated that about 80% of infectious diseases are due to biofilm mode of growth. Biofilm forming ability of bacteria imparts antimicrobial resistance that leads to many persistent and chronic bacterial infections. The world is becoming increasingly under the threat of entering the “post-antibiotic era”, an era in which the rate of death from bacterial infections is higher than from cancer.\r\nThis review focus on P. aeruginosa biofilm forming ability; definition, developmental stages, and significance. In addition, the quorum sensing and the antibiotic resistance of this pathogen is discussed.\r\nKeywords: Biofilm; bacterial adhesion; Pseudomonas aeruginosa; antimicrobial resistance; quorum sensing.</jats:p>","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"42587141","pmcid":null,"openalex_id":"https://openalex.org/W3046189674","authors":[],"funders":[],"total_grants":0,"fwci":0.1627,"citation_percentile":0.490853,"influential_citations":0,"citation_trend":[{"year":2022,"count":2},{"year":2024,"count":1},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"http://imed.pub/ojs/index.php/IAJAA/article/download/2369/2102","host_type":"journal"},{"url":"http://imed.pub/ojs/index.php/IAJAA/article/download/2369/2102","host_type":"publisher"},{"url":"https://doi.org/10.3823/846","host_type":"journal"}],"fields_of_study":["Bacterial biofilms and quorum sensing","Antibiotic Resistance in Bacteria","Oral microbiology and periodontitis research","Humans","Female","Pancreatic Neoplasms","Retrospective Studies","Carcinoma, Pancreatic Ductal","Male","Aged","Nutrition Assessment","Aged, 80 and over","Nutritional Status","Geriatric Assessment","Middle Aged","Antineoplastic Agents","Proportional Hazards Models","Survival Rate"],"mesh_terms":["Humans","Female","Pancreatic Neoplasms","Retrospective Studies","Carcinoma, Pancreatic Ductal","Male","Aged","Nutrition Assessment","Aged, 80 and over","Nutritional Status","Geriatric Assessment","Middle Aged","Antineoplastic Agents","Proportional Hazards Models","Survival Rate"],"keywords":["Biofilm","Pseudomonas aeruginosa","Quorum sensing","Microbiology","Antimicrobial","Antibiotic resistance","Biology","Antibiotics","Virulence","Human pathogen","Pathogen","Bacteria","Pathogenic bacteria","Cachexia","Geriatric nutritional risk index","Nutritional status","Pancreatic cancer","Risk stratification","Supportive care"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T19:25:49.924034Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}