{"doi":"10.3802/jgo.2013.24.4.376","title":"The roles of ARID1A in gynecologic cancer","abstract":null,"journal":"Journal of Gynecologic Oncology","year":2013,"id":606057,"datarank":0.6190701577567639,"base_score":4.127134385045092,"endowment":4.127134385045092,"self_citation_contribution":0.6190701577567639,"citation_network_contribution":0.0,"self_endowment_contribution":0.6190701577567639,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":61,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":22226,"name":"Ie-Ming Shih","orcid":null,"position":1,"is_corresponding":false},{"id":97252,"name":"Tsui-Lien Mao","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The roles of ARID1A in gynecologic cancer","abstract":"One of the exciting findings in recent cancer genome studies is the discovery of somatic mutations in several chromatin remodeling genes. These studies not only illuminate the emerging roles of chromatin remodeling in the pathogenesis of human cancer but also provide molecular genetic basis of aberrant epigenomic regulation as one of the key mechanisms driving cancer development. This is because chromatin remodeling influences a variety of DNA activities such as replication, transcription, repair, methylation, and recombination. Among the mutated chromatin remodeling genes reported, ARID1A is frequently mutated in a variety of human cancers, especially in endometrium-related neoplasms including ovarian clear cell carcinoma, ovarian endometrioid carcinomas, and uterine endometrioid carcinomas, all of which arise from endometrial epithelium. This review will summarize the recent advances in studying the roles of ARID1A mutations in gynecologic cancers with special emphasis on how this new knowledge will further extend our understanding of the pathogenesis of endometrium-related carcinomas.","is_dataset_classified":null,"base_score":4.127134385045092,"endowment":4.127134385045092,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24167674","pmcid":"PMC3805919","openalex_id":"https://openalex.org/W1991758615","authors":[],"funders":[{"funder_name":"Taiwan National Science Council (NSC)","grant_id":"100-2320-B-002-081","title":null},{"funder_name":"NIH/NCI","grant_id":"CA165807","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R21 CA165807","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R21CA165807-01","title":"Tumor Suppressor Role of ARID1A"}],"total_grants":4,"fwci":2.6132,"citation_percentile":0.89925692,"influential_citations":0,"citation_trend":[{"year":2014,"count":5},{"year":2015,"count":8},{"year":2016,"count":6},{"year":2017,"count":4},{"year":2018,"count":8},{"year":2019,"count":4},{"year":2020,"count":8},{"year":2021,"count":2},{"year":2022,"count":8},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"http://ejgo.org/Synapse/Data/PDFData/1114JGO/jgo-24-376.pdf","host_type":"journal"},{"url":"http://ejgo.org/Synapse/Data/PDFData/1114JGO/jgo-24-376.pdf","host_type":"publisher"},{"url":"https://synapse.koreamed.org/DOIx.php?id=10.3802/jgo.2013.24.4.376","host_type":"publisher"},{"url":"https://synapse.koreamed.org/pdf/10.3802/jgo.2013.24.4.376","host_type":"publisher"},{"url":"https://ejgo.org/DOIx.php?id=10.3802/jgo.2013.24.4.376","host_type":"publisher"},{"url":"https://doi.org/10.3802/jgo.2013.24.4.376","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24167674","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3805919","host_type":"repository"},{"url":"http://synapse.koreamed.org/Synapse/Data/PDFData/1114JGO/jgo-24-376.pdf","host_type":"Unpaywall"},{"url":"https://europepmc.org/articles/PMC3805919","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3805919?pdf=render","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/pmc3805919?pdf=render","host_type":""},{"url":"http://dx.doi.org/10.3802/jgo.2013.24.4.376","host_type":""},{"url":"https://dx.doi.org/10.3802/jgo.2013.24.4.376","host_type":""}],"fields_of_study":["Chromatin Remodeling and Cancer","Cancer Mechanisms and Therapy","Ovarian cancer diagnosis and treatment","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":[],"keywords":["ARID1A","Chromatin remodeling","Chromatin","Epigenomics","Cancer research","Endometrial cancer","Medicine","DNA methylation","Epigenetics","Cancer","Ovarian cancer","Biology","Bioinformatics","Gene","Genetics","Mutation","Internal medicine","Gene expression","Endometriosis","Baf250a","Review Article"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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