{"doi":"10.3791/65804","title":"Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses","abstract":"A critical challenge in translational research is establishing a viable and efficient interface between patient care in the operating room (OR) and the research laboratory. Here, we developed a protocol for acquiring high-quality liquid biopsies for molecular analyses from the aqueous humor and the vitreous from patients undergoing eye surgery. In this workflow, a Mobile Operating Room Lab Interface (MORLI) cart equipped with a computer, a barcode scanner, and lab instruments, including onboard cold storage, is used to obtain and archive human biological samples. A web-based data privacy-compliant database enables annotating each sample over its lifetime, and a cartesian coordinate system allows tracking each barcoded specimen in storage, enabling quick and accurate retrieval of samples for downstream analyses. Molecular characterization of human tissue samples not only serves as a diagnostic tool (e.g., to distinguish between infectious endophthalmitis and other non-infectious intraocular inflammation) but also represents an important component of translational research, allowing the identification of new drug targets, development of new diagnostic tools, and personalized therapeutics.","journal":"Journal of Visualized Experiments","year":2023,"id":352995,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9401,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":372994,"name":"Teja Chemudupati","orcid":null,"position":1,"is_corresponding":false},{"id":769741,"name":"Aarushi Kumar","orcid":null,"position":2,"is_corresponding":false},{"id":1019760,"name":"Ditte K. Rasmussen","orcid":"0009-0007-0542-5189","position":3,"is_corresponding":false},{"id":1098859,"name":"Karen M. Wai","orcid":"0000-0001-8980-2242","position":4,"is_corresponding":false},{"id":664540,"name":"Robert T. Chang","orcid":"0000-0002-2950-7951","position":5,"is_corresponding":false},{"id":1020507,"name":"Artis A. Montague","orcid":null,"position":6,"is_corresponding":false},{"id":371907,"name":"Peter H. Tang","orcid":"0000-0002-4516-4880","position":7,"is_corresponding":false},{"id":285420,"name":"Alexander G. Bassuk","orcid":"0000-0002-4067-2157","position":8,"is_corresponding":false},{"id":213032,"name":"Antoine Dufour","orcid":"0000-0002-3429-4188","position":9,"is_corresponding":false},{"id":1099234,"name":"Prithvi Mruthrunjaya","orcid":null,"position":10,"is_corresponding":false},{"id":317223,"name":"Vinit B. Mahajan","orcid":"0000-0003-1886-1741","position":11,"is_corresponding":false},{"id":930777,"name":"Julian Wolf","orcid":"0000-0002-3470-9697","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T01:12:54.209378Z","pmid":"37747194","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}