{"doi":"10.3791/61536","title":"A Novel Pavlovian Fear Conditioning Paradigm to Study Freezing and Flight Behavior","abstract":null,"journal":"Journal of Visualized Experiments","year":2021,"id":628995,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":762010,"name":"Jonathan P. Fadok","orcid":"0000-0002-0608-5151","position":1,"is_corresponding":false},{"id":832898,"name":"Chandrashekhar D. Borkar","orcid":"0000-0003-3636-2356","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Novel Pavlovian Fear Conditioning Paradigm to Study Freezing and Flight Behavior","abstract":"Fear- and anxiety-related behaviors significantly contribute to an organism's survival. However, exaggerated defensive responses to perceived threat are characteristic of various anxiety disorders, which are the most prevalent form of mental illness in the United States. Discovering the neurobiological mechanisms responsible for defensive behaviors will aid in the development of novel therapeutic interventions. Pavlovian fear conditioning is a widely used laboratory paradigm to study fear-related learning and memory. A major limitation of traditional Pavlovian fear conditioning paradigms is that freezing is the only defensive behavior monitored. We recently developed a modified Pavlovian fear conditioning paradigm that allows us to study both conditioned freezing and flight (also known as escape) behavior within individual subjects. This model employs higher intensity footshocks and a greater number of pairings between the conditioned stimulus and unconditioned stimulus. Additionally, this conditioned flight paradigm utilizes serial presentation of pure tone and white noise auditory stimuli as the conditioned stimulus. Following conditioning in this paradigm, mice exhibit freezing behavior in response to the tone stimulus, and flight responses during the white noise. This conditioning model can be applied to the study of rapid and flexible transitions between behavioral responses necessary for survival.","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33491674","pmcid":"PMC8593929","openalex_id":"https://openalex.org/W3119103886","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH122561","title":null}],"total_grants":1,"fwci":1.1596,"citation_percentile":0.74174349,"influential_citations":0,"citation_trend":[{"year":2022,"count":2},{"year":2023,"count":4},{"year":2024,"count":5},{"year":2025,"count":7},{"year":2026,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8593929","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8593929","host_type":"repository"},{"url":"https://www.jove.com/t/61536/a-novel-pavlovian-fear-conditioning-paradigm-to-study-freezing-flight","host_type":"publisher"},{"url":"https://doi.org/10.3791/61536","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33491674","host_type":"repository"}],"fields_of_study":["Memory and Neural Mechanisms","Receptor Mechanisms and Signaling","Stress Responses and Cortisol"],"mesh_terms":["Animals","Behavior, Animal","Conditioning, Classical","Escape Reaction","Extinction, Psychological","Fear","Female","Freezing","Male","Memory","Mice, Inbred C57BL","Video Recording","Freezing Reaction, Cataleptic","Mice"],"keywords":["Classical conditioning","Fear conditioning","Psychology","Freezing behavior","Anxiety","Stimulus (psychology)","Conditioning","Neuroscience","Measures of conditioned emotional response","Neutral stimulus","Unconditioned stimulus","Auditory stimuli","Cognitive psychology","Developmental psychology","Amygdala","Perception"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T15:55:35.139823Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}