{"doi":"10.3791/59841-v","title":"Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)","abstract":"Most methods for conducting meta-analysis of voxel-based neuroimaging studies do not assess whether effects are not null, but whether there is a convergence of peaks of statistical significance, and reduce the assessment of the evidence to a binary classification exclusively based on p-values (i.e., voxels can only be \"statistically significant\" or \"non-statistically significant\"). Here, we detail how to conduct a meta-analysis using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI), a novel method that uses a standard permutation test to assess whether effects are not null. We also show how to grade the strength of the evidence according to a set of criteria that considers a range of statistical significance levels (from more liberal to more conservative), the amount of data or the detection of potential biases (e.g., small-study effect and excess of significance). To exemplify the procedure, we detail the conduction of a meta-analysis of voxel-based morphometry studies in obsessive-compulsive disorder, and we provide all the data already extracted from the manuscripts to allow the reader to replicate the meta-analysis easily. SDM-PSI can also be used for meta-analyses of functional magnetic resonance imaging, diffusion tensor imaging, position emission tomography and surface-based morphometry studies.","journal":"Journal of Visualized Experiments","year":2019,"id":11399,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2019-11-27","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":17199,"name":"Aleix Solanes","orcid":"0000-0002-2491-200X","position":1,"is_corresponding":false},{"id":148,"name":"John P. A. Ioannidis","orcid":"0000-0003-3118-6859","position":3,"is_corresponding":false},{"id":57147,"name":"Carla Torrent","orcid":"0000-0003-0335-582X","position":5,"is_corresponding":false},{"id":57148,"name":"Brisa Solé","orcid":"0000-0003-1673-8248","position":6,"is_corresponding":false},{"id":57149,"name":"Caterina  Mar Bonnín","orcid":null,"position":7,"is_corresponding":false},{"id":17207,"name":"Eduard Vieta","orcid":"0000-0002-0548-0053","position":8,"is_corresponding":false},{"id":17206,"name":"David Mataix-Cols","orcid":null,"position":9,"is_corresponding":false},{"id":17209,"name":"Joaquim Radua","orcid":null,"position":10,"is_corresponding":false},{"id":57150,"name":"Anton Albajes‐Eizagirre","orcid":"0000-0001-7767-6568","position":11,"is_corresponding":false},{"id":17194,"name":"Miquel A. Fullana","orcid":"0000-0003-3863-5223","position":12,"is_corresponding":false},{"id":15117,"name":"Paolo Fusar‐Poli","orcid":"0000-0003-3582-6788","position":13,"is_corresponding":false},{"id":57151,"name":"Caterina del Mar Bonnín","orcid":"0000-0002-1197-1596","position":14,"is_corresponding":false},{"id":17215,"name":"David Mataix‐Cols","orcid":"0000-0002-4545-0924","position":15,"is_corresponding":false},{"id":17217,"name":"Joaquim Raduà","orcid":"0000-0003-1240-5438","position":16,"is_corresponding":false},{"id":57145,"name":"Anton Albajes-Eizagirre","orcid":null,"position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}