{"doi":"10.3758/bf03332114","title":"Neural integrative activities of nucleus accumbens subregions in relation to learning and motivation","abstract":null,"journal":"Psychobiology","year":1999,"id":639230,"datarank":0.793995723708674,"base_score":5.293304824724492,"endowment":5.293304824724492,"self_citation_contribution":0.793995723708674,"citation_network_contribution":0.0,"self_endowment_contribution":0.793995723708674,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":198,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1092136,"name":"Ann E. Kelley","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Neural integrative activities of nucleus accumbens subregions in relation to learning and motivation","abstract":"In recent years, there has been much interest in the functional specializations of nucleus accumbens subregions. The two zones within the nucleus accumbens that have received considerable attention are the accumbens core, consisting of ventral striatal tissue surrounding the anterior commissure, and the accumbens shell, which envelops the core on its medial, ventral, and lateral borders. Differential connectivity and histochemical profiles suggest that these two subterritories may have distinctive behavioral roles with regard to the regulation of motivated behavior. Experiments focusing primarily on amino acid–coded neurotransmitter systems in these regions—that is, glutamate and gamma-amino butyric acid (GABA)—have revealed specific and contrasting functions of the core and the shell. It is proposed that the accumbens core, and specifically N -methyl- d -aspartate receptor-dependent plasticity within this area, is part of a network critical for appetitive instrumental learning, in which a motor response becomes “stamped in” when followed by a rewarding stimulus or event. The accumbens shell, particularly GABA and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors within the shell, is implicated in the executive control of brain feeding circuits and may also represent a key area at which appetitive and aversive stimuli interact to control behavioral selection. These functional specializations within the nucleus accumbens subregions may be integrated through the coordination of activity within striatal neuronal ensembles that communicate with complex networks of limbic, thalamic, and prefrontal circuitry.","is_dataset_classified":null,"base_score":5.293304824724492,"endowment":5.293304824724492,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19767382","pmcid":null,"openalex_id":"https://openalex.org/W1578111329","authors":[],"funders":[],"total_grants":0,"fwci":4.0349,"citation_percentile":0.95518852,"influential_citations":0,"citation_trend":[{"year":2012,"count":13},{"year":2013,"count":2},{"year":2014,"count":7},{"year":2015,"count":5},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2018,"count":4},{"year":2019,"count":2},{"year":2020,"count":3},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":3}],"oa_status":"gold","license":"https://www.springer.com/tdm","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.3758/BF03332114.pdf","host_type":"journal"},{"url":"https://link.springer.com/content/pdf/10.3758/BF03332114.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.3758/BF03332114/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.3758/bf03332114","host_type":"journal"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Neurotransmitter Receptor Influence on Behavior","Memory and Neural Mechanisms"],"mesh_terms":[],"keywords":["Nucleus accumbens","Neuroscience","Psychology","Dopamine","Glutamate receptor","Basal ganglia","Biology","Receptor","Central nervous system"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T23:17:46.159751Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}