{"doi":"10.37506/ijfmt.v15i3.15753","title":"Analysis of the Characteristics of SARS-Cov-2 Spike  Compared to SARS-Cov Spike and Its Role in the Pathogenesis  of Infection– A Literature Review","abstract":"<jats:p>The spread of COVID-19 that caused by SARS-CoV-2 happened very fast &amp; has infected many people. WHO reported 1,051,635 cases of COVID-19 and 56,985 confirmed deaths caused by COVID-19 as of April 4, 2020. SARS-CoV-2 is a novel coronavirus that originates from betacoronavirus together with SARS-CoV.This study aims to find and understand the differences between the SARS-CoV-2 and SARS-CoV spikes in the infection and the spread of the resulting disease. This is a literature studies obtained from national journal articles indexed by SINTA and international journals indexed by Scimago or Scopus and published in 2015-2020. We concluded that there is a difference between the SARS-CoV-2 spike and the SARS-CoV spike, so that it can affect the spread of the disease. SARS-CoV-2 has a furin cleavage site that absent in SARS-CoV. The existence of this furin cleavage site can help the activation and the efficiency of the infection of the SARS-CoV-2 and increases its transmissibility to organs and populations when compared to viruses without furin cleavage sites such as SARS-CoV.</jats:p>","journal":"Indian Journal of Forensic Medicine &amp; Toxicology","year":2021,"id":657388,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1716125,"name":"Sihning E.J.T","orcid":null,"position":1,"is_corresponding":false},{"id":1716126,"name":"Diah Purwaningsar","orcid":null,"position":2,"is_corresponding":false},{"id":1716127,"name":"Retno Budiarti","orcid":null,"position":3,"is_corresponding":false},{"id":1716124,"name":"Galih Kathleyana","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Analysis of the Characteristics of SARS-Cov-2 Spike  Compared to SARS-Cov Spike and Its Role in the Pathogenesis  of Infection– A Literature Review","abstract":"<jats:p>The spread of COVID-19 that caused by SARS-CoV-2 happened very fast &amp; has infected many people. WHO reported 1,051,635 cases of COVID-19 and 56,985 confirmed deaths caused by COVID-19 as of April 4, 2020. SARS-CoV-2 is a novel coronavirus that originates from betacoronavirus together with SARS-CoV.This study aims to find and understand the differences between the SARS-CoV-2 and SARS-CoV spikes in the infection and the spread of the resulting disease. This is a literature studies obtained from national journal articles indexed by SINTA and international journals indexed by Scimago or Scopus and published in 2015-2020. We concluded that there is a difference between the SARS-CoV-2 spike and the SARS-CoV spike, so that it can affect the spread of the disease. SARS-CoV-2 has a furin cleavage site that absent in SARS-CoV. The existence of this furin cleavage site can help the activation and the efficiency of the infection of the SARS-CoV-2 and increases its transmissibility to organs and populations when compared to viruses without furin cleavage sites such as SARS-CoV.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":null,"pmcid":null,"openalex_id":"https://openalex.org/W3178372139","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.07456716,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://medicopublication.com/index.php/ijfmt/article/download/15753/14129","host_type":"journal"},{"url":"https://medicopublication.com/index.php/ijfmt/article/download/15753/14129","host_type":"publisher"},{"url":"http://medicopublication.com/index.php/ijfmt/article/download/15753/14129","host_type":"publisher"},{"url":"https://doi.org/10.37506/ijfmt.v15i3.15753","host_type":"journal"}],"fields_of_study":["SARS-CoV-2 and COVID-19 Research","COVID-19 diagnosis using AI","Diverse Scientific Research Studies"],"mesh_terms":[],"keywords":["Furin","Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","Coronavirus","Virology","Coronavirus disease 2019 (COVID-19)","Cleavage (geology)","Betacoronavirus","2019-20 coronavirus outbreak","Spike (software development)","Disease","Biology","Medicine","Outbreak","Infectious disease (medical specialty)","Pathology","Computer science","Enzyme"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T00:53:52.672483Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}