{"doi":"10.3748/wjg.v30.i22.2829","title":"Management of non-alcoholic fatty liver disease: Lifestyle changes","abstract":"<jats:p>In this editorial, we commented on a recently released manuscript by Zeng et al  in the World Journal of Gastroenterology . We focused specifically on lifestyle changes in patients with non-alcoholic fatty liver disease (NAFLD). NAFLD is a hepatic manifestation of the metabolic syndrome, which ultimately leads to advanced hepatic fibrosis, cirrhosis, and hepatocellular carcinoma and affects more than 25% of the population globally. Existing therapeutic strategies against NAFLD such as pharmacologic therapies focus on liver protection, anti-inflammation, and regulating disease-related metabolic disorder symptoms. Although several drugs are in late-stage development, potent drugs against the diseases are lacking. Additionally, existing surgical approaches such as bariatric surgery are not routinely used to treat NAFLD. Intervening in patients’ unhealthy lifestyles, such as weight loss through dietary changes and exercises to ameliorate patient-associated metabolic disorders and metabolic syndrome, is the first-line treatment for patients with NAFLD. With sufficient intrinsic motivation and adherence, the management of unhealthy lifestyles can reduce the severity of the disease, improve the quality of life, and increase the survival expectancy of patients with NAFLD.</jats:p>","journal":"World Journal of Gastroenterology","year":2024,"id":618527,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1213708,"name":"Yang Liu","orcid":"0000-0001-6235-200X","position":1,"is_corresponding":false},{"id":1595729,"name":"Hao Lv","orcid":"0000-0002-7580-0155","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Management of non-alcoholic fatty liver disease: Lifestyle changes","abstract":"<jats:p>In this editorial, we commented on a recently released manuscript by Zeng et al  in the World Journal of Gastroenterology . We focused specifically on lifestyle changes in patients with non-alcoholic fatty liver disease (NAFLD). NAFLD is a hepatic manifestation of the metabolic syndrome, which ultimately leads to advanced hepatic fibrosis, cirrhosis, and hepatocellular carcinoma and affects more than 25% of the population globally. Existing therapeutic strategies against NAFLD such as pharmacologic therapies focus on liver protection, anti-inflammation, and regulating disease-related metabolic disorder symptoms. Although several drugs are in late-stage development, potent drugs against the diseases are lacking. Additionally, existing surgical approaches such as bariatric surgery are not routinely used to treat NAFLD. Intervening in patients’ unhealthy lifestyles, such as weight loss through dietary changes and exercises to ameliorate patient-associated metabolic disorders and metabolic syndrome, is the first-line treatment for patients with NAFLD. With sufficient intrinsic motivation and adherence, the management of unhealthy lifestyles can reduce the severity of the disease, improve the quality of life, and increase the survival expectancy of patients with NAFLD.</jats:p>","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38947294","pmcid":null,"openalex_id":"https://openalex.org/W4399449543","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":9},{"year":2026,"count":4}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://rcastoragev2.blob.core.windows.net/7bc4e20b726e50417e4dc1abf82c925d/PMC6824058.pdf","host_type":"journal"},{"url":"https://rcastoragev2.blob.core.windows.net/7bc4e20b726e50417e4dc1abf82c925d/PMC6824058.pdf","host_type":"publisher"},{"url":"https://www.wjgnet.com/1007-9327/full/v30/i22/2829.htm","host_type":"publisher"},{"url":"https://doi.org/10.3748/wjg.v30.i22.2829","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38947294","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11212717","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11212717/pdf/WJG-30-2829.pdf","host_type":"repository"}],"fields_of_study":["Liver Disease Diagnosis and Treatment","Diet, Metabolism, and Disease","Alcohol Consumption and Health Effects"],"mesh_terms":["Healthy Lifestyle","Humans","Life Style","Quality of Life","Risk Factors","Weight Loss","Exercise","Metabolic Syndrome","Risk Reduction Behavior","Bariatric Surgery","Non-alcoholic Fatty Liver Disease"],"keywords":["Fatty liver","Medicine","Alcoholic liver disease","Internal medicine","Gastroenterology","Disease","Cirrhosis","Non-alcoholic fatty liver disease","Physical Activity","Lifestyle","Physical Exercise","Mediterranean Diet","Low-calorie Diet"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T04:38:08.380120Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}