{"doi":"10.3748/wjg.v10.i22.3261","title":"Expression of vascular endothelial growth factor-C and the relationship between lymphangiogenesis and lymphatic metastasis in colorectal cancer","abstract":null,"journal":"World Journal of Gastroenterology","year":2004,"id":650134,"datarank":0.5676284450877392,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.0,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1695110,"name":"Yi-Tao Jia","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Expression of vascular endothelial growth factor-C and the relationship between lymphangiogenesis and lymphatic metastasis in colorectal cancer","abstract":"AIM: To investigate the expression of vascular endothelial growth factor-C (VEGF-C) and the relationship between VEGF-C and lymphangiogenesis, lymph node metastasis in colorectal cancer. METHODS: Fifty six cases of colorectal cancer were selected randomly. Expression of VEGF-C was detected by immunohistochemistry, and lymphatic vessels were stained by enzyme histochemical method. RESULTS: VEGF-C expression was found in 66.7% (37/56) patients. In VEGF-C positive and negative patients, the lymphatic vessel density was 25.16+/-7.52 and 17.14+/-7.22, respectively (P<0.05). The rate of lymph node metastasis in VEGF-C positive patients (81.1%) was significantly higher than that in the negative group (42.1%). CONCLUSION: VEGF-C expression may induce lymphangiogenesis in colorectal cancer, as a result, tumor cells can entry the lymphatic vessels easily. VEGF-C may serve as a useful prognotic factor in colorectal carcinoma.","is_dataset_classified":null,"base_score":3.784189633918261,"endowment":3.784189633918261,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15484296","pmcid":"PMC4572291","openalex_id":"https://openalex.org/W2109749818","authors":[],"funders":[],"total_grants":0,"fwci":2.3455,"citation_percentile":0.88433451,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2018,"count":3},{"year":2020,"count":1},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://www.wjgnet.com/1007-9327/full/v10/i22/3261.htm","host_type":"journal"},{"url":"https://www.wjgnet.com/1007-9327/full/v10/i22/3261.htm","host_type":"publisher"},{"url":"http://www.wjgnet.com/1007-9327/full/v10/i22/3261.htm","host_type":"publisher"},{"url":"https://doi.org/10.3748/wjg.v10.i22.3261","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15484296","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4572291","host_type":"repository"}],"fields_of_study":["Lymphatic System and Diseases","Lymphatic Disorders and Treatments","Angiogenesis and VEGF in Cancer","Adult","Aged","Colorectal Neoplasms","Female","Humans","Immunohistochemistry","Lymphangiogenesis","Lymphatic Metastasis","Lymphatic Vessels","Male","Middle Aged","Prognosis","Vascular Endothelial Growth Factor C"],"mesh_terms":["Adult","Aged","Female","Humans","Immunohistochemistry","Lymphatic Metastasis","Male","Middle Aged","Prognosis","Colorectal Neoplasms","Vascular Endothelial Growth Factor C","Lymphangiogenesis","Lymphatic Vessels"],"keywords":["Lymphangiogenesis","Colorectal cancer","Vascular endothelial growth factor C","Lymphatic vessel","Lymphatic system","Medicine","Immunohistochemistry","Vascular endothelial growth factor","Pathology","Lymphatic Endothelium","Metastasis","Lymph node metastasis","Lymphovascular invasion","Cancer","Internal medicine","Oncology","Vascular endothelial growth factor A","VEGF receptors"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T04:54:04.341687Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}