{"doi":"10.37247/pans.1.2020.3","title":"Decoupling the Effects of the Amyloid Precursor Protein from Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain","abstract":"Amyloid precursor protein (APP) is the precursor to A plaques. The cytoplasmic domain of APP mediates attachment of vesicles to molecular motors for axonal transport. In APP-KO mice transport of Mn 2+ is decreased. In old transgenic mice expressing mutated human (APP SwInd ) linked to Familial Alzheimer's Disease, with both expression of APP SwInd and plaques, the rate and destination of Mn 2+ axonal transport is altered, as detected by time-lapse manganese-enhanced magnetic resonance imaging (MEMRI) of the brain in living mice. To determine the relative contribution of expression of APP SwInd versus plaque on transport dynamics, we developed a Tet-off system to decouple expression of APP SwInd from plaque, and then studied hippocampal to forebrain transport by MEMRI. Three groups of mice were","journal":"Vide Leaf, Hyderabad eBooks","year":2020,"id":133110,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9509,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":588999,"name":"Taylor W. Uselman","orcid":"0000-0002-3856-5248","position":1,"is_corresponding":false},{"id":589226,"name":"Daniel Barto","orcid":null,"position":2,"is_corresponding":false},{"id":589227,"name":"Frances Cháves","orcid":null,"position":3,"is_corresponding":false},{"id":487880,"name":"Russell E. Jacobs","orcid":"0000-0002-1382-8486","position":4,"is_corresponding":false},{"id":589000,"name":"Elaine L. Bearer","orcid":"0000-0002-8390-8529","position":5,"is_corresponding":false},{"id":588998,"name":"Christopher S. Medina","orcid":"0000-0002-2545-6536","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-18T23:16:14.071209Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}