{"doi":"10.37212/jcnos.334114","title":"Is Hypericum perforatum agonist or antagonist of TRPC6 in neurons?","abstract":"<jats:p xml:lang=\"en\">Transient receptor potential canonical 6\r\n(TRPC6) channel is a family of transient receptor superfamily. Hyperforin is an\r\nactive component of Hypericum species including Hypericum perforatum (HPer). In the review paper, the author summarizes the recent information between\r\nTRPC6-induced Ca2+ entry, HPer and hyperforin to understand the\r\netiology of the neurological diseases and potential therapeutic strategies. \r\nThe TRPC6 in several cell types is activated by\r\n2-Aminoethoxydiphenylborane (2-APB), 4,5 triphosphate (IP3) &amp;nbsp;and diacylglycerol (DAG) pathways, although it\r\nwas inhibited in the cells by several non-specific antagonists including\r\ngadolinium and lanthanum. Results of limited studies indicated that hyperforin\r\ncaused intracellular Ca2+ elevations through TRPC6 activation in\r\nneurons and cells, although the intracellular\r\nCa2+ elevation results were\r\nnot confirmed by many recent studies. Release Ca2+ from internal stores instead of extracellular Ca2+\r\nentry through activation of TRPC6 channel in neurons of brain was also\r\nreported. The TRPC6-induced Ca2+ influx was inhibited in brain by\r\nactive components of some antioxidants. \r\n\r\nIn conclusion, the present literature\r\ninformation shows that interaction between TRPC6-induced\r\nCa2+ entry and hyperforin in neurons and cell lines are too complex and it has not been\r\nclarified yet.\r\n\r\n</jats:p>","journal":"Journal of Cellular Neuroscience and Oxidative Stress","year":2016,"id":28376,"datarank":0.1171671084365774,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.01319503135258559,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.01319503135258559,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":159147,"name":"Mustafa NAZIROĞLU","orcid":"0000-0003-0887-6974","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24523987","pmcid":null,"openalex_id":"https://openalex.org/W2988210217","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.14390557,"influential_citations":0,"citation_trend":[{"year":2020,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://dergipark.org.tr/tr/download/article-file/334181","host_type":"journal"},{"url":"https://dergipark.org.tr/tr/download/article-file/334181","host_type":"BRONZE"},{"url":"https://dergipark.org.tr/tr/download/article-file/334181","host_type":"publisher"},{"url":"https://doi.org/10.37212/jcnos.334114","host_type":"journal"},{"url":"http://dergipark.gov.tr/jcnos/issue/30872/334114","host_type":"repository"},{"url":"https://dergipark.org.tr/tr/pub/jcnos/issue/30872/334114","host_type":"journal"}],"fields_of_study":["Natural Compound Pharmacology Studies","Ion Channels and Receptors","Plant Molecular Biology Research","Chemistry","Medicine","Biology"],"mesh_terms":[],"keywords":["Hypericum perforatum","Agonist","Antagonist","Pharmacology","Traditional medicine","Medicine","Internal medicine","Receptor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T21:21:57.289257Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}