{"doi":"10.36351/pjo.v37i2.1204","title":"Outcome of Intraoperative Mitomycin C Injection in Trabeculectomy and Phacotrabeculectomy in Patients with Glaucoma","abstract":"<jats:p>Purpose:  To determine the efficacy and safety of per-operative mitomycin C injection during trabeculectomy and combined phaco-trabeculectomy in different types of glaucoma.\r\nStudy Design:  Interventional case series.\r\nPlace and Duration of Study:  Shifa International, between January 2018 to July 2020.\r\nMethods:  Thirty one patients requiring trabeculectomy or Phaco-trabeculectomy with mitomycin C because of maximum tolerable anti-glaucoma treatment or poor compliance were included in the study. Out of these 15 in group A underwent simple trabeculectomy with intra-operative mitomycin C and 16 patients in group B underwent phacotrabeculectomy with intra-operative mitomycin C and IOL implantation. All patients underwent an eye examination (including IOP and visual acuity) before surgery and then afterwards at 1 week, 1 month, 2 months, 6 months and 1 year. Main outcome measures were best corrected visual acuity, intra-ocular pressure and number of medications at base line and post-operatively.\r\nResults:  Demographic results of the two groups were similar. Mean follow-up period was 1 year, mean IOP was 11 in group Aand 15.5 in group B in last follow-up.Mean IOP reduction at 1 year was significant in both group A and B (p = 0.001, p = 0.022 respectively). Hypotony, post-operative inflammatory membrane and bleb fibrosis were the main complications in group A and group B.\r\nConclusion:  Trabeculectomy with mitomycin C and phaco-trabeculectomy with mitomycin C are equally successful at lowering IOP in common types of glaucoma permitting significant and safe reduction of anti-glaucoma medications for atleast 1 year after surgery.\r\nKey Words:  Mitomycin, Glaucoma, Intra ocular pressure.</jats:p>","journal":"Pakistan Journal of Ophthalmology","year":2021,"id":636785,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1653071,"name":"Hajra Farooq","orcid":null,"position":1,"is_corresponding":false},{"id":1653073,"name":"Momina Faisal","orcid":null,"position":2,"is_corresponding":false},{"id":1653070,"name":"Saadia Farooq","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Outcome of Intraoperative Mitomycin C Injection in Trabeculectomy and Phacotrabeculectomy in Patients with Glaucoma","abstract":"<jats:p>Purpose:  To determine the efficacy and safety of per-operative mitomycin C injection during trabeculectomy and combined phaco-trabeculectomy in different types of glaucoma.\r\nStudy Design:  Interventional case series.\r\nPlace and Duration of Study:  Shifa International, between January 2018 to July 2020.\r\nMethods:  Thirty one patients requiring trabeculectomy or Phaco-trabeculectomy with mitomycin C because of maximum tolerable anti-glaucoma treatment or poor compliance were included in the study. Out of these 15 in group A underwent simple trabeculectomy with intra-operative mitomycin C and 16 patients in group B underwent phacotrabeculectomy with intra-operative mitomycin C and IOL implantation. All patients underwent an eye examination (including IOP and visual acuity) before surgery and then afterwards at 1 week, 1 month, 2 months, 6 months and 1 year. Main outcome measures were best corrected visual acuity, intra-ocular pressure and number of medications at base line and post-operatively.\r\nResults:  Demographic results of the two groups were similar. Mean follow-up period was 1 year, mean IOP was 11 in group Aand 15.5 in group B in last follow-up.Mean IOP reduction at 1 year was significant in both group A and B (p = 0.001, p = 0.022 respectively). Hypotony, post-operative inflammatory membrane and bleb fibrosis were the main complications in group A and group B.\r\nConclusion:  Trabeculectomy with mitomycin C and phaco-trabeculectomy with mitomycin C are equally successful at lowering IOP in common types of glaucoma permitting significant and safe reduction of anti-glaucoma medications for atleast 1 year after surgery.\r\nKey Words:  Mitomycin, Glaucoma, Intra ocular pressure.</jats:p>","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19767382","pmcid":null,"openalex_id":"https://openalex.org/W3151763976","authors":[],"funders":[],"total_grants":0,"fwci":0.1839,"citation_percentile":0.46568389,"influential_citations":0,"citation_trend":[{"year":2023,"count":1}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://doi.org/10.36351/pjo.v37i2.1204","host_type":"journal"},{"url":"https://doi.org/10.36351/pjo.v37i2.1204","host_type":"publisher"},{"url":"https://localhost/ojs/index.php/pjo/article/download/1204/922","host_type":"publisher"}],"fields_of_study":["Glaucoma and retinal disorders","Ocular Oncology and Treatments","Retinal Diseases and Treatments"],"mesh_terms":[],"keywords":["Trabeculectomy","Medicine","Glaucoma","Mitomycin C","Intraocular pressure","Glaucoma surgery","Visual acuity","Ophthalmology","Surgery"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"No poverty"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T17:44:00.910718Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}