{"doi":"10.36278/jeaht.26.4.172","title":"A Method for Simultaneous Quantification of Chlorine Dioxide and Hypochlorous Acid/hypochlorite and its Application to Disinfection Products","abstract":"<jats:p>A novel high performance chromatographic method was devised to simultaneously quantify chlorine dioxide and hypochlorous acid/hypochlorite, leveraging their similar chemical properties but distinct toxicities. In this study, it consists of a two-step derivatization reaction: The first step is the reaction of hypochlorous acid/hypochlorite with 2,6-dimethylphenol in a water matrix to produce 4-chloro-2,6-dimethylphenol; the second step is a reaction in which iodine ions added after the first step react with chlorine dioxide to produce iodine and then react with 2,6-dimethylphenol to produce 4-iodo-2,6-dimethylphenol. It was confirmed that the concentration of 4-chloro-2,6-dimethylphenol produced was proportional to the total concentration of hypochlorous acid/hypochlorite, and the concentration of 4-iodo-2,6-dimethylphenol was proportional to the concentration of chlorine dioxide. With a detection limit of 0.011 mg/L for chlorine dioxide and 0.009 mg/L for hypochlorous acid/hypochlorite, the calibration curve showed excellent linearity (r2=0.999) in disinfectant solution. This sensitive and selective method is well-suited for the routine analysis of chlorine dioxide and hypochlorous acid/hypochlorite in water and disinfection byproducts.</jats:p>","journal":"Journal of Environmental Analysis, Health and Toxicology","year":2023,"id":677529,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1770306,"name":"Vu Thi Hoang Van","orcid":null,"position":1,"is_corresponding":false},{"id":1770308,"name":"Seo Yeong Choi","orcid":null,"position":2,"is_corresponding":false},{"id":1770311,"name":"Ho-Sang Shin","orcid":null,"position":3,"is_corresponding":false},{"id":1770304,"name":"Kyeong-Yun Choi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Method for Simultaneous Quantification of Chlorine Dioxide and Hypochlorous Acid/hypochlorite and its Application to Disinfection Products","abstract":"<jats:p>A novel high performance chromatographic method was devised to simultaneously quantify chlorine dioxide and hypochlorous acid/hypochlorite, leveraging their similar chemical properties but distinct toxicities. In this study, it consists of a two-step derivatization reaction: The first step is the reaction of hypochlorous acid/hypochlorite with 2,6-dimethylphenol in a water matrix to produce 4-chloro-2,6-dimethylphenol; the second step is a reaction in which iodine ions added after the first step react with chlorine dioxide to produce iodine and then react with 2,6-dimethylphenol to produce 4-iodo-2,6-dimethylphenol. It was confirmed that the concentration of 4-chloro-2,6-dimethylphenol produced was proportional to the total concentration of hypochlorous acid/hypochlorite, and the concentration of 4-iodo-2,6-dimethylphenol was proportional to the concentration of chlorine dioxide. With a detection limit of 0.011 mg/L for chlorine dioxide and 0.009 mg/L for hypochlorous acid/hypochlorite, the calibration curve showed excellent linearity (r2=0.999) in disinfectant solution. This sensitive and selective method is well-suited for the routine analysis of chlorine dioxide and hypochlorous acid/hypochlorite in water and disinfection byproducts.</jats:p>","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26207759","pmcid":null,"openalex_id":"https://openalex.org/W4390900788","authors":[],"funders":[],"total_grants":0,"fwci":0.2516,"citation_percentile":0.53704698,"influential_citations":0,"citation_trend":[{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"gold","license":"http://creativecommons.org/licenses/by-nc/4.0/","oa_locations":[{"url":"http://www.jeaht.org/upload/pdf/jeaht-26-4-172.pdf","host_type":"journal"},{"url":"http://www.jeaht.org/upload/pdf/jeaht-26-4-172.pdf","host_type":"publisher"},{"url":"http://jeaht.org/upload/pdf/jeaht-26-4-172.pdf","host_type":"publisher"},{"url":"http://jeaht.org/journal/view.php?doi=10.36278/jeaht.26.4.172","host_type":"publisher"},{"url":"https://doi.org/10.36278/jeaht.26.4.172","host_type":"journal"}],"fields_of_study":["Water Treatment and Disinfection","Chemical Analysis and Environmental Impact","Toxic Organic Pollutants Impact"],"mesh_terms":[],"keywords":["Hypochlorous acid","Chlorine dioxide","Hypochlorite","Chlorine","Disinfectant","Sodium hypochlorite","Chemistry","Detection limit","Calcium hypochlorite","Iodine","Chromatography","Chloramine","Nuclear chemistry","Inorganic chemistry","Organic chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T04:14:47.164339Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}