{"doi":"10.36227/techrxiv.21396978","title":"A Modular 512 Channel Neural Signal Acquisition ASIC for High Density 4096 Channel Electrophysiology","abstract":"<p>The complexity of information processing in the brain requires development of technologies that can provide spatial and temporal resolution by means of dense electrode arrays paired with high-channel-count signal acquisition electronics. In this work, we present a modular 512-channel neural recording circuit that is scalable to up to 4096 simultaneously recording channels. The neural readout application-specific integrated circuit (ASIC) uses a dense 8.2 mm x 6.8 mm 2D-layout to enable high-channel-count, creating an ultralight 350 mg flexible module. The module can be deployed on headstages for small animals like rodents and songbirds, and can be integrated with a variety of electrode arrays.</p> <p>The chip was fabricated in a 0.18 μm 1.8-V CMOS technology and dissipates a total of 125 mW. Each DC coupled channel features a gain and bandwidth programmable analog front-end, along with 14b analog-to-digital conversion at speeds up to 30 kS/s. Additionally, each front-end includes programmable electrode plating and electrode impedance measurement capability. We present both standalone and in vivo measurements results, demonstrating readout of spikes and field potentials that are modulated by a sensory input.</p>","journal":null,"year":2022,"id":312776,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1010622,"name":"Carl Grace","orcid":"0000-0002-6619-128X","position":1,"is_corresponding":false},{"id":1010621,"name":"Peter Denes","orcid":"0000-0001-7686-708X","position":2,"is_corresponding":false},{"id":404977,"name":"John Hermiz","orcid":"0000-0002-3450-0738","position":3,"is_corresponding":false},{"id":1010620,"name":"Aikaterini Papadopoulou","orcid":"0000-0001-9440-6076","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-19T00:33:40.460845Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}