{"doi":"10.34133/2022/9819154","title":"Biomimetic Alveolus-on-a-Chip for SARS-CoV-2 Infection Recapitulation","abstract":"<jats:p>\n            SARS-CoV-2 has caused a severe pneumonia pandemic worldwide with high morbidity and mortality. How to develop a preclinical model for recapitulating SARS-CoV-2 pathogenesis is still urgent and essential for the control of the pandemic. Here, we have established a 3D biomimetic alveolus-on-a-chip with mechanical strain and extracellular matrix taken into consideration. We have validated that the alveolus-on-a-chip is capable of recapitulating key physiological characteristics of human alveolar units, which lays a fundamental basis for viral infection studies at the organ level. Using virus-analogous chemicals and pseudovirus, we have explored virus pathogenesis and blocking ability of antibodies during viral infection. This work provides a favorable platform for SARS-CoV-2-related researches and has a great potential for physiology and pathophysiology studies of the human lung at the organ level\n            <jats:italic>in vitro.</jats:italic>\n          </jats:p>","journal":"Research","year":2022,"id":629058,"datarank":0.586803450814222,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":0.0,"self_endowment_contribution":0.586803450814222,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1629005,"name":"Changmin Shao","orcid":null,"position":1,"is_corresponding":false},{"id":422346,"name":"Xiaoyu Yu","orcid":"0000-0003-2885-4959","position":2,"is_corresponding":false},{"id":1629006,"name":"Ruipei Xie","orcid":null,"position":3,"is_corresponding":false},{"id":628579,"name":"Chen Yang","orcid":"0000-0001-6011-4067","position":4,"is_corresponding":false},{"id":1629007,"name":"Yulong Sun","orcid":null,"position":5,"is_corresponding":false},{"id":437093,"name":"Shaohua Yang","orcid":null,"position":6,"is_corresponding":false},{"id":1629008,"name":"Wangjian He","orcid":null,"position":7,"is_corresponding":false},{"id":1014939,"name":"Ye Xu","orcid":"0000-0003-4322-244X","position":8,"is_corresponding":false},{"id":1629009,"name":"Qihui Fan","orcid":"0000-0002-6408-8369","position":9,"is_corresponding":false},{"id":355349,"name":"Fangfu Ye","orcid":"0000-0003-1279-105X","position":10,"is_corresponding":false},{"id":1286630,"name":"Ting Cao","orcid":"0000-0002-5436-6724","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Biomimetic Alveolus-on-a-Chip for SARS-CoV-2 Infection Recapitulation","abstract":"<jats:p>\n            SARS-CoV-2 has caused a severe pneumonia pandemic worldwide with high morbidity and mortality. How to develop a preclinical model for recapitulating SARS-CoV-2 pathogenesis is still urgent and essential for the control of the pandemic. Here, we have established a 3D biomimetic alveolus-on-a-chip with mechanical strain and extracellular matrix taken into consideration. We have validated that the alveolus-on-a-chip is capable of recapitulating key physiological characteristics of human alveolar units, which lays a fundamental basis for viral infection studies at the organ level. Using virus-analogous chemicals and pseudovirus, we have explored virus pathogenesis and blocking ability of antibodies during viral infection. This work provides a favorable platform for SARS-CoV-2-related researches and has a great potential for physiology and pathophysiology studies of the human lung at the organ level\n            <jats:italic>in vitro.</jats:italic>\n          </jats:p>","is_dataset_classified":null,"base_score":3.912023005428146,"endowment":3.912023005428146,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35224503","pmcid":"PMC8841031","openalex_id":"https://openalex.org/W4210729876","authors":[],"funders":[{"funder_name":"Chinese Academy of Sciences","grant_id":"YJKYYQ20190034","title":null},{"funder_name":"Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province","grant_id":"WIUCASK19006","title":null},{"funder_name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","grant_id":"2021007","title":null},{"funder_name":"Emergency Project of Wenzhou","grant_id":"ZY202005","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2020YFA0908200","title":null}],"total_grants":5,"fwci":3.2154,"citation_percentile":0.92944951,"influential_citations":0,"citation_trend":[{"year":2022,"count":6},{"year":2023,"count":19},{"year":2024,"count":12},{"year":2025,"count":8},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://downloads.spj.sciencemag.org/research/2022/9819154.pdf","host_type":"journal"},{"url":"https://downloads.spj.sciencemag.org/research/2022/9819154.pdf","host_type":"publisher"},{"url":"http://downloads.spj.sciencemag.org/research/2022/9819154.pdf","host_type":"publisher"},{"url":"https://spj.science.org/doi/pdf/10.34133/2022/9819154","host_type":"publisher"},{"url":"https://doi.org/10.34133/2022/9819154","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35224503","host_type":"repository"},{"url":"https://doaj.org/article/716fc0faa4864d74b54ba6320f66b4a7","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8841031","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8841031","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8841031?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["3D Printing in Biomedical Research","Innovative Microfluidic and Catalytic Techniques Innovation","Inhalation and Respiratory Drug Delivery"],"mesh_terms":[],"keywords":["Pathogenesis","Virus","Virology","Viral pneumonia","Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","Pandemic","Pneumonia","Sars virus","Coronavirus disease 2019 (COVID-19)","Medicine","Biology","Immunology","Pathology","Disease","Infectious disease (medical specialty)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T16:19:27.926640Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}