{"doi":"10.34133/2022/9816272","title":"Photothermal Nano-Vaccine Promoting Antigen Presentation and Dendritic Cells Infiltration for Enhanced Immunotherapy of Melanoma via Transdermal Microneedles Delivery","abstract":"<jats:p>\n            Immunotherapy has demonstrated the potential to cure melanoma, while the current response rate is still unsatisfactory in clinics. Extensive evidence indicates the correlation between the efficacy and pre-existing T-cell in tumors, whereas the baseline T-cell infiltration is lacking in low-response melanoma patients. Herein, we demonstrated the critical contribution of dendritic cells (DCs) on melanoma survival and baseline T-cell level, as well as the efficacy of immunotherapy. Capitalized on this fact, we developed a photothermal nano-vaccine to simultaneously promote tumor antigens presentation and DCs infiltration for enhanced immunotherapy. The nano-vaccine was composed of polyserotonin (PST) core and tannic acid (TA)/Mn\n            <jats:sup>2+</jats:sup>\n            coordination-based metal-organic-framework (MOF) shell for\n            <jats:italic>β</jats:italic>\n            -catenin silencing DNAzyme loading, which was further integrated into dissolving microneedles to allow noninvasive and transdermal administration at melanoma skin. The nano-vaccine could rapidly penetrate skin upon microneedles insertion and exert a synergistically amplified photothermal effect to induce immunogenic cell death (ICD). The MOF shell then dissociated and released Mn\n            <jats:sup>2+</jats:sup>\n            as a cofactor to self-activate DNAzyme for\n            <jats:italic>β</jats:italic>\n            -catenin suppression, which in turn caused a persistent CCL4 excretion to promote the infiltration of DCs into the tumor. Meanwhile, the liberated PST core could effectively capture and facilitate tumor antigens presentation to DCs. As a result, potent antitumor efficacies were achieved for both primary and distal tumors without any extra treatment, indicating the great promise of such a nano-vaccine for on-demand personalized immunotherapy of melanoma.\n          </jats:p>","journal":"Research","year":2022,"id":615518,"datarank":0.5676284450877392,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.0,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1586534,"name":"Ruimin Chang","orcid":null,"position":1,"is_corresponding":false},{"id":1586535,"name":"Benliang Wei","orcid":null,"position":2,"is_corresponding":false},{"id":587263,"name":"Yao Fu","orcid":"0009-0008-6810-7337","position":3,"is_corresponding":false},{"id":241111,"name":"Xiang Chen","orcid":"0000-0002-2499-8261","position":4,"is_corresponding":false},{"id":342970,"name":"Hong Liu","orcid":"0000-0002-3464-1418","position":5,"is_corresponding":false},{"id":319193,"name":"Wenhu Zhou","orcid":"0000-0003-3794-661X","position":6,"is_corresponding":false},{"id":1586533,"name":"Jiaojiao Zhu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Photothermal Nano-Vaccine Promoting Antigen Presentation and Dendritic Cells Infiltration for Enhanced Immunotherapy of Melanoma via Transdermal Microneedles Delivery","abstract":"<jats:p>\n            Immunotherapy has demonstrated the potential to cure melanoma, while the current response rate is still unsatisfactory in clinics. Extensive evidence indicates the correlation between the efficacy and pre-existing T-cell in tumors, whereas the baseline T-cell infiltration is lacking in low-response melanoma patients. Herein, we demonstrated the critical contribution of dendritic cells (DCs) on melanoma survival and baseline T-cell level, as well as the efficacy of immunotherapy. Capitalized on this fact, we developed a photothermal nano-vaccine to simultaneously promote tumor antigens presentation and DCs infiltration for enhanced immunotherapy. The nano-vaccine was composed of polyserotonin (PST) core and tannic acid (TA)/Mn\n            <jats:sup>2+</jats:sup>\n            coordination-based metal-organic-framework (MOF) shell for\n            <jats:italic>β</jats:italic>\n            -catenin silencing DNAzyme loading, which was further integrated into dissolving microneedles to allow noninvasive and transdermal administration at melanoma skin. The nano-vaccine could rapidly penetrate skin upon microneedles insertion and exert a synergistically amplified photothermal effect to induce immunogenic cell death (ICD). The MOF shell then dissociated and released Mn\n            <jats:sup>2+</jats:sup>\n            as a cofactor to self-activate DNAzyme for\n            <jats:italic>β</jats:italic>\n            -catenin suppression, which in turn caused a persistent CCL4 excretion to promote the infiltration of DCs into the tumor. Meanwhile, the liberated PST core could effectively capture and facilitate tumor antigens presentation to DCs. As a result, potent antitumor efficacies were achieved for both primary and distal tumors without any extra treatment, indicating the great promise of such a nano-vaccine for on-demand personalized immunotherapy of melanoma.\n          </jats:p>","is_dataset_classified":null,"base_score":3.784189633918261,"endowment":3.784189633918261,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36157510","pmcid":"PMC9484834","openalex_id":"https://openalex.org/W4294664058","authors":[],"funders":[{"funder_name":"China Postdoctoral Science Foundation Funded Project","grant_id":"2022T150741","title":null},{"funder_name":"China Postdoctoral Science Foundation Funded Project","grant_id":"2021M693558","title":null},{"funder_name":"Innovation-Driven Project of Central South University","grant_id":"2020CX043","title":null},{"funder_name":"Natural Science Foundation of Hunan Province for Outstanding Young Scholars","grant_id":"2019JJ30040","title":null},{"funder_name":"Youth Talent Program of Hunan Province","grant_id":"2019RS2009","title":null},{"funder_name":"Natural Science Foundation of China for Outstanding Young Scholars","grant_id":"82022060","title":null},{"funder_name":"National Basic Research Program of China","grant_id":"2019YFE0120800","title":null},{"funder_name":"National Basic Research Program of China","grant_id":"2019YFA0111600","title":null},{"funder_name":"Science and Technology Innovation Program of Hunan Province","grant_id":"2020RC2010","title":null},{"funder_name":"Science and Technology Innovation Program of Hunan Province","grant_id":"2021RC3020","title":null},{"funder_name":"Natural Science Foundation of Hunan Province in China","grant_id":"2021JJ20092","title":null},{"funder_name":"Natural Science Foundation of Hunan Province in China","grant_id":"2021JJ20084","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"31800979","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"U1903125","title":null}],"total_grants":14,"fwci":2.939,"citation_percentile":0.92660396,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":9},{"year":2024,"count":13},{"year":2025,"count":16},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://downloads.spj.sciencemag.org/research/2022/9816272.pdf","host_type":"journal"},{"url":"https://downloads.spj.sciencemag.org/research/2022/9816272.pdf","host_type":"publisher"},{"url":"http://downloads.spj.sciencemag.org/research/2022/9816272.pdf","host_type":"publisher"},{"url":"http://downloads.spj.sciencemag.org/research/2022/9816272.xml","host_type":"publisher"},{"url":"https://spj.science.org/doi/pdf/10.34133/2022/9816272","host_type":"publisher"},{"url":"https://doi.org/10.34133/2022/9816272","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36157510","host_type":"repository"},{"url":"https://doaj.org/article/5cbce82747714386b4c1b76f1700947f","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9484834","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9484834","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9484834?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Immunotherapy and Immune Responses","Immune Cell Function and Interaction","Cancer Immunotherapy and Biomarkers"],"mesh_terms":[],"keywords":["Immunotherapy","Photothermal therapy","Melanoma","Cancer research","Medicine","Infiltration (HVAC)","Antigen","Dendritic cell","Transdermal","Immune system","Immunology","Materials science","Pharmacology","Nanotechnology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T20:14:05.757138Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}