{"doi":"10.3410/f.737584496.793573108","title":"Faculty Opinions recommendation of The genetic architecture of the human cerebral cortex.","abstract":"The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. PMID: 32193296 Funding information This work was supported by: NIA NIH HHS, United States Grant ID: U01 AG049505 NIA NIH HHS, United States Grant ID: R01 AG059874 NIA NIH HHS, United States Grant ID: R01 AG022381 NIDA NIH HHS, United States Grant ID: RC2 DA029475 NIA NIH HHS, United States Grant ID: RF1 AG051710 NHLBI NIH HHS, United States Grant ID: N01HC85081 Medical Research Council, United Kingdom Grant ID: G9815508 NINDS NIH HHS, United States Grant ID: R01 NS042867 NCRR NIH HHS, United States Grant ID: S10 RR023401 NIMH NIH HHS, United States Grant ID: RC1 MH089257 NIMH NIH HHS, United States Grant ID: R01 MH119243 NHLBI NIH HHS, United States Grant ID: N01HC85080 NIMH NIH HHS, United States Grant ID: R01 MH085646 NIMH NIH HHS, United States Grant ID: R01 MH118349 NCATS NIH HHS, United States Grant ID: UL1 TR001881 NHLBI NIH HHS, United States Grant ID: R01 HL087641 NIA NIH HHS, United States Grant ID: R01 AG023629 Medical Research Council, United Kingdom Grant ID: MR/L010305/1 NHLBI NIH HHS, United States Grant ID: N01HC85079 NCRR NIH HHS, United States Grant ID: U24 RR025736 NCRR NIH HHS, United States Grant ID: S10 RR023043 NIMH NIH HHS, United States Grant ID: R01 MH083824 NICHD NIH HHS, United States Grant ID: R01 HD061414 NINDS NIH HHS, United States Grant ID: R01 NS073134 NIH HHS, United States Grant ID: S10 OD023696 Biotechnology and Biological Sciences Research Council, United Kingdom Grant ID: BB/F019394/1 NIMH NIH HHS, United States Grant ID: R01 MH112180 NIA NIH HHS, United States Grant ID: P30 AG010129 NIA NIH HHS, United States Grant ID: R03 AG046413 Wellcome Trust, United Kingdom NIDDK NIH HHS, United States Grant ID: R01 DK092127 Medical Research Council, United Kingdom Grant ID: G0700704 NIDA NIH HHS, United States Grant ID: R01 DA018673 NHLBI NIH HHS, United States Grant ID: N01HC25195 NHLBI NIH HHS, United States Grant ID: HHSN268201100005C NLM NIH HHS, United States Grant ID: R01 LM012535 NHLBI NIH HHS, United States Grant ID: N01HC85083 NHLBI NIH HHS, United States Grant ID: R01 HL070825 NHLBI NIH HHS, United States Grant ID: HHSN268201100009C NIMH NIH HHS, United States Grant ID: P50 MH103222 NCRR NIH HHS, United States Grant ID: U24 RR021992 NIDA NIH HHS, United States Grant ID: R00 DA023549 NIA NIH HHS, United States Grant ID: R01 AG033040 NCATS NIH HHS, United States Grant ID: UL1 TR000153 NIMH NIH HHS, United States Grant ID: R00 MH101367 NIMH NIH HHS, United States Grant ID: U24 MH068457 NIA NIH HHS, United States Grant ID: R56 AG058854 NHLBI NIH HHS, United States Grant ID: R01 HL084099 NIMH NIH HHS, United States Grant ID: K01 MH099232 NIMH NIH HHS, United States Grant ID: R01 MH079799 NHLBI NIH HHS, United States Grant ID: HHSN268201500001I NIBIB NIH HHS, United States Grant ID: R01 EB000840 Medical Research Council, United King","journal":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","year":2020,"id":133619,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5422,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":29916,"name":"Genevieve Konopka","orcid":"0000-0002-3363-7302","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-18T23:16:17.577688Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}