{"doi":"10.3410/f.733438619.793574559","title":"Faculty Opinions recommendation of A noncanonical PPARγ/RXRα-binding sequence regulates leptin expression in response to changes in adipose tissue mass.","abstract":"analyzed data; Y.Z. conceived/designed the study and performed the majority of the experiments; O.S.D. developed the strategy and reagents for generating bacterial artificial chromosome transgenic (BACTG) mice; T.N. performed the purification of PPAR and RXR proteins; G.F. performed pronuclear injections for BACTG mice and some of the in vivo luciferase imaging; Y.-H.L. made the leptin enhancer 1 (LE1) and LE2 reporters, worked with Y.Z. on the construction of the BAC reporter clones, and helped plan the studies using these reagents; M.A.L. helped perform the PPAR ChIP-sequencing analysis; R.G.R. played a major role in planning the experiments, suggested the use of assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) instead of DNase-sequencing, suggested that leptin regulatory element 1 might be a weak PPARbinding site and provided purified protein to test this, provided a critical analysis of the data that were generated, and made many helpful suggestions; J.M.F. conceived the majority of the study; and Y.Z. and J.","journal":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","year":2020,"id":133059,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9435,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":286782,"name":"Heike Münzberg","orcid":null,"position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T23:16:14.071209Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}