{"doi":"10.3410/f.732523111.793575825","title":"Faculty Opinions recommendation of Biased Generation and In Situ Activation of Lung Tissue-Resident Memory CD4 T Cells in the Pathogenesis of Allergic Asthma.","abstract":"Asthma is a chronic inflammatory disease mediated by allergen-specific CD4 T cells which promote lung inflammation through recruitment of cellular effectors into the lung. A subset of lung T cells can persist as tissue-resident memory T cells (TRM) following infection and allergen induction, although the generation and role of TRM in asthma persistence and pathogenesis remain unclear. Here we used a mouse model of chronic exposure to intranasal house dust mite extract (HDM) to dissect how the lung TRM are generated and function in the persistence and pathogenesis of allergic airway disease. We demonstrate that both CD4 + and CD8 + T cells infiltrate into the lung tissue during acute HDM exposure; however, only CD4 + TRM, and not CD8 + TRM persist longterm following cessation of HDM administration. Lung CD4 + TRM cells are localized around airways and rapidly reactivated upon allergen re-exposure accompanied by the rapid induction of airway hyperresponsiveness independent of circulating T cells. Lung CD4 + TRM activation to HDM challenge is also accompanied by increased recruitment and activation of dendritic cells in the lungs. Our results indicate that lung CD4 + TRM can perpetuate allergenspecific sensitization and direct early inflammatory signals that promote rapid lung pathology,","journal":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","year":2020,"id":133148,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9565,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":588312,"name":"Gabrielle T. Belz","orcid":"0000-0002-9660-9587","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-18T23:16:17.577688Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}