{"doi":"10.3390/vaccines8040631","title":"A Novel Approach for the Treatment of T Cell Malignancies: Targeting T Cell Receptor Vβ Families","abstract":"Peripheral T cell lymphomas (PTCLs) are generally chemotherapy resistant and have a poor prognosis. The lack of targeted immunotherapeutic approaches for T cell malignancies results in part from potential risks associated with targeting broadly expressed T cell markers, namely T cell depletion and clinically significant immune compromise. The knowledge that the T cell receptor (TCR) β chain in human α/β TCRs are grouped into Vβ families that can each be targeted by a monoclonal antibody can therefore be exploited for therapeutic purposes. Here, we develop a flexible approach for targeting TCR Vβ families by engineering T cells to express a chimeric CD64 protein that acts as a high affinity immune receptor (IR). We found that CD64 IR-modified T cells can be redirected with precision to T cell targets expressing selected Vβ families by combining CD64 IR-modified T cells with a monoclonal antibody directed toward a specific TCR Vβ family in vitro and in vivo. These findings provide proof of concept that TCR Vβ-family-specific T cell lysis can be achieved using this novel combination cell-antibody platform and illuminates a path toward high precision targeting of T cell malignancies without substantial immune compromise.","journal":"Vaccines","year":2020,"id":115895,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9563,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":542659,"name":"Katarzyna Urbańska","orcid":"0009-0006-9167-0879","position":1,"is_corresponding":false},{"id":543270,"name":"Prannda Sharma","orcid":null,"position":2,"is_corresponding":false},{"id":407370,"name":"Reza Nejati","orcid":"0000-0002-2188-156X","position":3,"is_corresponding":false},{"id":542660,"name":"Lauren Shaw","orcid":"0000-0002-4104-2261","position":4,"is_corresponding":false},{"id":281051,"name":"Megan S. Lim","orcid":"0000-0002-0415-2867","position":5,"is_corresponding":false},{"id":273372,"name":"Stephen J. Schuster","orcid":"0000-0002-3376-8978","position":6,"is_corresponding":false},{"id":542661,"name":"Daniel Powell","orcid":"0000-0003-4995-6057","position":7,"is_corresponding":false},{"id":542658,"name":"Jie Wang","orcid":"0000-0002-5602-0487","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-18T23:13:40.596604Z","pmid":"33142718","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}