{"doi":"10.3390/vaccines8030540","title":"GMMA Is a Versatile Platform to Design Effective Multivalent Combination Vaccines","abstract":"Technology platforms are an important strategy to facilitate the design, development and implementation of vaccines to combat high-burden diseases that are still a threat for human populations, especially in low- and middle-income countries, and to address the increasing number and global distribution of pathogens resistant to antimicrobial drugs. Generalized Modules for Membrane Antigens (GMMA), outer membrane vesicles derived from engineered Gram-negative bacteria, represent an attractive technology to design affordable vaccines. Here, we show that GMMA, decorated with heterologous polysaccharide or protein antigens, leads to a strong and effective antigen-specific humoral immune response in mice. Importantly, GMMA promote enhanced immunogenicity compared to traditional formulations (e.g., recombinant proteins and glycoconjugate vaccines), without negative impact to the anti-GMMA immune response. Our findings support the use of GMMA as a \"plug and play\" technology for the development of effective combination vaccines targeting different bugs at the same time.","journal":"Vaccines","year":2020,"id":56608,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":84,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.961,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":296595,"name":"Renzo Alfini","orcid":null,"position":1,"is_corresponding":false},{"id":296596,"name":"Roberta Di Benedetto","orcid":null,"position":2,"is_corresponding":false},{"id":294532,"name":"Francesca Necchi","orcid":"0000-0003-1239-8696","position":3,"is_corresponding":false},{"id":294533,"name":"Fabiola Schiavo","orcid":"0000-0002-2574-460X","position":4,"is_corresponding":false},{"id":294534,"name":"Francesca Mancini","orcid":"0000-0003-2122-9480","position":5,"is_corresponding":false},{"id":294535,"name":"Martina Carducci","orcid":"0000-0001-6633-567X","position":6,"is_corresponding":false},{"id":294536,"name":"Elena Palmieri","orcid":"0000-0002-1248-5389","position":7,"is_corresponding":false},{"id":296597,"name":"Cristiana Balocchi","orcid":null,"position":8,"is_corresponding":false},{"id":294537,"name":"Gianmarco Gasperini","orcid":"0000-0001-5411-7667","position":9,"is_corresponding":false},{"id":296598,"name":"Brunella Brunelli","orcid":null,"position":10,"is_corresponding":false},{"id":294538,"name":"Paolo Costantino","orcid":"0000-0002-9166-2194","position":11,"is_corresponding":false},{"id":294539,"name":"Roberto Adamo","orcid":"0000-0001-5228-6088","position":12,"is_corresponding":false},{"id":294540,"name":"Diego Piccioli","orcid":"0000-0002-5809-4455","position":13,"is_corresponding":false},{"id":294541,"name":"Allan Saul","orcid":"0000-0003-0665-4091","position":14,"is_corresponding":false},{"id":294531,"name":"Francesca Micoli","orcid":"0000-0001-8243-3181","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-18T21:06:09.605575Z","pmid":"32957610","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}