{"doi":"10.3390/v5020605","title":"Carbohydrate-Related Inhibitors of Dengue Virus Entry","abstract":"<jats:p>Dengue virus (DENV), which is transmitted by Aedes mosquitoes, causes fever and hemorrhagic disorders in humans. The virus entry process mediated through host receptor molecule(s) is crucial for virus propagation and the pathological progression of dengue disease. Therefore, elucidation of the molecular mechanisms underlying virus entry is essential for an understanding of dengue pathology and for the development of effective new anti-dengue agents. DENV binds to its receptor molecules mediated through a viral envelope (E) protein, followed by incorporation of the virus-receptor complex inside cells. The fusion between incorporated virus particles and host endosome membrane under acidic conditions is mediated through the function of DENV E protein. Carbohydrate molecules, such as sulfated glycosaminoglycans (GAG) and glycosphingolipids, and carbohydrate-recognition proteins, termed lectins, inhibit virus entry. This review focuses on carbohydrate-derived entry inhibitors, and also introduces functionally related compounds with similar inhibitory mechanisms against DENV entry.</jats:p>","journal":"Viruses","year":2013,"id":19123,"datarank":1.9826217442453085,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"self_citation_contribution":0.5983476069846413,"citation_network_contribution":1.384274137260667,"self_endowment_contribution":0.5983476069846413,"citer_contribution":1.384274137260667,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":52,"citers_with_citation_signal":48,"citers_with_endowment":48,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":130554,"name":"Tomoko Abe","orcid":null,"position":1,"is_corresponding":false},{"id":130555,"name":"Takashi Suzuki","orcid":null,"position":2,"is_corresponding":false},{"id":130553,"name":"Kazuya Hidari","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23389466","pmcid":"PMC3640517","openalex_id":"https://openalex.org/W2147849935","authors":[],"funders":[],"total_grants":0,"fwci":3.9917,"citation_percentile":0.93384329,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":8},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":6},{"year":2018,"count":4},{"year":2019,"count":8},{"year":2020,"count":7},{"year":2021,"count":4},{"year":2022,"count":7},{"year":2023,"count":2},{"year":2024,"count":2},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1999-4915/5/2/605/pdf?version=1431415265","host_type":"journal"},{"url":"https://www.mdpi.com/1999-4915/5/2/605/pdf?version=1431415265","host_type":"GOLD"},{"url":"https://www.mdpi.com/1999-4915/5/2/605/pdf?version=1431415265","host_type":"publisher"},{"url":"https://www.mdpi.com/1999-4915/5/2/605/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/v5020605","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23389466","host_type":"repository"},{"url":"https://doaj.org/article/5742c58b4ba14c0785e64a0bf248715b","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3640517","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/v5020605","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3640517","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3640517?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Mosquito-borne diseases and control","Malaria Research and Control","Studies on Chitinases and Chitosanases","Biology","Medicine","Chemistry","Animals","Antiviral Agents","Carbohydrates","Dengue","Dengue Virus","Humans","Membrane Fusion","Virus Internalization"],"mesh_terms":["Animals","Antiviral Agents","Carbohydrates","Dengue","Dengue Virus","Humans","Membrane Fusion","Virus Internalization"],"keywords":["Dengue virus","Antibody-dependent enhancement","Viral entry","Virus","Endosome","Entry inhibitor","Dengue fever","Virology","Biology","Lipid bilayer fusion","Viral envelope","Receptor","Flavivirus","Glycoprotein","Biochemistry","Viral replication"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.12819399.v1","title":"Additional file 1 of Production of dengue virus-like particles serotype-3 in silkworm larvae and their ability to elicit a humoral immune response in mice","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.12819399","title":"Additional file 1 of Production of dengue virus-like particles serotype-3 in silkworm larvae and their ability to elicit a humoral immune response in mice","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-04T02:02:52.474757Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}