{"doi":"10.3390/v3050520","title":"Antiviral Inhibition of Enveloped Virus Release by Tetherin/BST-2: Action and Counteraction","abstract":"<jats:p>Tetherin (BST2/CD317) has been recently recognized as a potent interferon-induced antiviral molecule that inhibits the release of diverse mammalian enveloped virus particles from infected cells. By targeting an immutable structure common to all these viruses, the virion membrane, evasion of this antiviral mechanism has necessitated the development of specific countermeasures that directly inhibit tetherin activity. Here we review our current understanding of the molecular basis of tetherin’s mode of action, the viral countermeasures that antagonize it, and how virus/tetherin interactions may affect viral transmission and pathogenicity.</jats:p>","journal":"Viruses","year":2011,"id":638178,"datarank":0.6952093482344455,"base_score":4.634728988229636,"endowment":4.634728988229636,"self_citation_contribution":0.6952093482344455,"citation_network_contribution":0.0,"self_endowment_contribution":0.6952093482344455,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":102,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1657416,"name":"Suzanne Willey","orcid":null,"position":1,"is_corresponding":false},{"id":270799,"name":"Stuart J. 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Here we review our current understanding of the molecular basis of tetherin’s mode of action, the viral countermeasures that antagonize it, and how virus/tetherin interactions may affect viral transmission and pathogenicity.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21994744","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"082274","title":"The role of the Human Immunodeficiency Virus Type 1 (HIV-1) Vpu protein in overcoming a novel antiviral restriction of virus release."},{"funder_name":"UK Research and Innovation","grant_id":"G0801937","title":"The role of Vpu and tetherin in HIV/AIDS pathogenesis"}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"CC BY","oa_locations":[{"url":"https://doi.org/10.3390/v3050520","host_type":""},{"url":"https://www.mdpi.com/1999-4915/3/5/520/pdf","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/21994744","host_type":""},{"url":"http://dx.doi.org/10.3390/v3050520","host_type":""},{"url":"https://doaj.org/article/06a5d63eb6cf457fb1085b829fb891c0","host_type":""},{"url":"https://dx.doi.org/10.3390/v3050520","host_type":""},{"url":"https://univ-rennes.hal.science/hal-01121799v1","host_type":""},{"url":"https://doi.org/https://doi.org/10.3390/v3050520","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["570","restriction of enveloped virus release","Bone Marrow Stromal Antigen 2","viral countermeasure","610","Down-Regulation","HIV","HIV Infections","interferon","Review","GPI-Linked Proteins","Microbiology","QR1-502","[SDV] Life Sciences [q-bio]","Viral Proteins","Antigens, CD","Tetherin/BST2","Vpu","Humans","Virus Release","Protein Binding"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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