{"doi":"10.3390/v16091365","title":"Non-HIV Vaccine-Induced Immune Responses as Potential Baseline Immunogenicity Predictors of ALVAC-HIV and AIDSVAX B/E-Induced Immune Responses","abstract":"Identifying correlations between immune responses elicited via HIV and non-HIV vaccines could aid the search for correlates of HIV protection and increase statistical power in HIV vaccine-efficacy trial designs. An exploratory objective of the HVTN 097 phase 1b trial was to assess whether immune responses [focusing on those supported as correlates of risk (CoR) of HIV acquisition] induced via the RV144 pox-prime HIV vaccine regimen correlated with those induced via tetanus toxoid (TT) and/or hepatitis B virus (HBV) vaccines. We measured TT-specific and HBV-specific IgG-binding antibody responses and TT-specific and HBV-specific CD4+ T-cell responses at multiple time points in HVTN 097 participants, and we assessed their correlations at peak time points with HIV vaccine (ALVAC-HIV and AIDSVAX B/E)-induced responses. Four correlations were significant [false discovery rate-adjusted p-value (FDR) ≤ 0.2]. Three of these four were with IgG-binding antibody responses to TT measured one month after TT receipt, with the strongest and most significant correlation [rho = 0.368 (95% CI: 0.096, 0.588; p = 0.008; FDR = 0.137)] being with IgG-binding antibody responses to MN gp120 gDneg (B protein boost) measured two weeks after the second ALVAC-HIV and AIDSVAX B/E boost. The fourth significant correlation [(rho = 0.361; 95% CI: 0.049, 0.609; p = 0.021; FDR = 0.137)] was between CD4+ T-cell responses to a hepatitis B surface antigen peptide pool, measured 2 weeks after the third HBV vaccination, and IgG-binding antibody responses to gp70BCaseAV1V2 (B V1V2 immune correlate), measured two weeks after the second ALVAC-HIV and AIDSVAX B/E boost. These moderate correlations imply that either vaccine, TT or HBV, could potentially provide a moderately useful immunogenicity predictor for the ALVAC-HIV and AIDSVAX B/E HIV vaccine regimen.","journal":"Viruses","year":2024,"id":471724,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9562,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":258350,"name":"S. Munir Alam","orcid":"0000-0003-0941-0703","position":1,"is_corresponding":false},{"id":52018,"name":"Erica Andersen‐Nissen","orcid":"0000-0001-9213-920X","position":2,"is_corresponding":false},{"id":539332,"name":"Lindsay N. Carpp","orcid":"0000-0003-0333-5925","position":3,"is_corresponding":false},{"id":302713,"name":"One Dintwe","orcid":"0000-0002-5642-7121","position":4,"is_corresponding":false},{"id":218076,"name":"Britta Flach","orcid":null,"position":5,"is_corresponding":false},{"id":355215,"name":"Nicole Grunenberg","orcid":"0000-0003-2565-3879","position":6,"is_corresponding":false},{"id":355214,"name":"Fatima Laher","orcid":"0000-0001-5231-9951","position":7,"is_corresponding":false},{"id":331738,"name":"Stephen C. De Rosa","orcid":"0000-0003-3871-4618","position":8,"is_corresponding":false},{"id":249714,"name":"Guido Ferrari","orcid":"0000-0001-7747-3349","position":9,"is_corresponding":false},{"id":355221,"name":"Craig Innes","orcid":"0000-0002-6872-5687","position":10,"is_corresponding":false},{"id":273592,"name":"Linda‐Gail Bekker","orcid":"0000-0002-0755-4386","position":11,"is_corresponding":false},{"id":288612,"name":"James G. Kublin","orcid":"0000-0003-1279-3741","position":12,"is_corresponding":false},{"id":52019,"name":"M. Juliana McElrath","orcid":"0000-0003-2276-7117","position":13,"is_corresponding":false},{"id":258351,"name":"Georgia D. Tomaras","orcid":"0000-0001-8076-1931","position":14,"is_corresponding":false},{"id":314444,"name":"Glenda Gray","orcid":"0000-0003-4649-1477","position":15,"is_corresponding":false},{"id":96350,"name":"Peter B. Gilbert","orcid":"0000-0002-2662-9427","position":16,"is_corresponding":false},{"id":394416,"name":"Ying Huang","orcid":"0000-0002-9655-7502","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T02:05:48.788780Z","pmid":"39339842","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}