{"doi":"10.3390/v16050666","title":"Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy?","abstract":"<jats:p>Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts. This challenge is partly attributed to the intricate nature of HIV-1 latency, wherein various host and viral factors participate in multiple physiological processes. While substantial progress has been made in discovering therapeutic targets for HIV-1 transcription, targets for the post-transcriptional regulation of HIV-1 infections have received less attention. However, cumulative evidence now suggests the pivotal contribution of post-transcriptional regulation to the viral latency in both in vitro models and infected individuals. In this review, we explore recent insights on post-transcriptional latency in HIV-1 and discuss the potential of its therapeutic targets, illustrating some host factors that restrict HIV-1 at the post-transcriptional level.</jats:p>","journal":"Viruses","year":2024,"id":647669,"datarank":0.4617911101630423,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.13220742356260937,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.13220742356260937,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":8,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1060553,"name":"Yasuko Tsunetsugu‐Yokota","orcid":"0000-0002-1168-8846","position":1,"is_corresponding":false},{"id":1687551,"name":"Mie Kobayashi-Ishihara","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy?","abstract":"<jats:p>Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts. This challenge is partly attributed to the intricate nature of HIV-1 latency, wherein various host and viral factors participate in multiple physiological processes. While substantial progress has been made in discovering therapeutic targets for HIV-1 transcription, targets for the post-transcriptional regulation of HIV-1 infections have received less attention. However, cumulative evidence now suggests the pivotal contribution of post-transcriptional regulation to the viral latency in both in vitro models and infected individuals. In this review, we explore recent insights on post-transcriptional latency in HIV-1 and discuss the potential of its therapeutic targets, illustrating some host factors that restrict HIV-1 at the post-transcriptional level.</jats:p>","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38793548","pmcid":"PMC11125802","openalex_id":"https://openalex.org/W4395666547","authors":[],"funders":[{"funder_name":"Takeda Science Foundation","grant_id":"#2022049218","title":null},{"funder_name":"Takeda Science Foundation","grant_id":"No number provided","title":null}],"total_grants":2,"fwci":1.8577,"citation_percentile":0.84344423,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":6},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1999-4915/16/5/666/pdf?version=1713969435","host_type":"journal"},{"url":"https://www.mdpi.com/1999-4915/16/5/666/pdf?version=1713969435","host_type":"publisher"},{"url":"https://www.mdpi.com/1999-4915/16/5/666/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/v16050666","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38793548","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11125802","host_type":"repository"},{"url":"https://doaj.org/article/57bba4449a1048bb8954209540227fac","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11125802/pdf/viruses-16-00666.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11125802","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11125802?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["HIV Research and Treatment","Mosquito-borne diseases and control","HIV/AIDS drug development and treatment"],"mesh_terms":["Humans","RNA Processing, Post-Transcriptional","HIV-1","HIV Infections","Gene Expression Regulation, Viral","Virus Latency","Host-Pathogen Interactions"],"keywords":["Latency (audio)","Human immunodeficiency virus (HIV)","Transcriptional regulation","Biology","Transcription (linguistics)","Virus latency","Computational biology","Virology","Viral replication","Virus","Immunology","Transcription factor","Bioinformatics","Genetics","Gene","Computer science","HIV-1","Restriction Factors","Latency Reversing Agents","Post-transcriptional Latency"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T01:43:08.096827Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}