{"doi":"10.3390/v15112162","title":"Immune Profiles in Multisystem Inflammatory Syndrome in Children with Cardiovascular Abnormalities","abstract":"BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C), a sequela of severe acute respiratory syndrome coronavirus-2 infection (SARS-CoV2), has been progressively reported worldwide, with cardiac involvement being a frequent presentation. Although the clinical and immunological characteristics of MIS-C with and without cardiac involvement have been described, the immunological differences between cardiac and non-cardiac MIS-C are not well understood. METHODS: = 64)) abnormalities. RESULTS: MIS-C children with cardiac manifestations presented with significantly increased levels of cytokines such as IFN-γ, IL-2, TNFα, IL-5, IL-1α, IL-1β, IL-6, IL-10 and IL-12p70 and chemokines such as CCL2, CCL3, CCL11 and CXCL10 in comparison to MIS-C children without cardiac manifestations. Clustering analysis revealed that cytokines and chemokines could clearly distinguish MIS-C children with and without cardiac manifestations. In addition, these responses significantly diminished and normalized 9 months after treatment. CONCLUSIONS: This is one of the first studies characterizing and differentiating systemic inflammation in MIS-C with and without cardiac involvement from a low- and middle-income country (LMIC). Our study contributes to the existing body of evidence and advances our knowledge of the immunopathogenesis of MIS-C in children.","journal":"Viruses","year":2023,"id":375858,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9653,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1060626,"name":"Aishwarya Venkataraman","orcid":"0000-0002-7360-9736","position":1,"is_corresponding":false},{"id":340196,"name":"Arul Nancy","orcid":"0000-0002-9561-8967","position":2,"is_corresponding":false},{"id":1138724,"name":"Nandhini Selvaraj","orcid":null,"position":3,"is_corresponding":false},{"id":341073,"name":"Kadar Moideen","orcid":null,"position":4,"is_corresponding":false},{"id":925741,"name":"Shaik Fayaz Ahamed","orcid":"0000-0002-5975-649X","position":5,"is_corresponding":false},{"id":1138725,"name":"Rachel Marriam Renji","orcid":null,"position":6,"is_corresponding":false},{"id":1138369,"name":"Sasidaran Kandasamy","orcid":"0000-0001-8031-0508","position":7,"is_corresponding":false},{"id":1138370,"name":"Sandip Kumar","orcid":"0000-0001-6836-7907","position":8,"is_corresponding":false},{"id":1138726,"name":"Muthiah Periyakuppan","orcid":null,"position":9,"is_corresponding":false},{"id":1138727,"name":"Thankgavelu Sangaralingam","orcid":null,"position":10,"is_corresponding":false},{"id":1138728,"name":"Poovazhagi Varadarajan","orcid":null,"position":11,"is_corresponding":false},{"id":1138729,"name":"Elilarasi Chelladurai","orcid":null,"position":12,"is_corresponding":false},{"id":299467,"name":"Subash Babu","orcid":"0000-0001-9783-8042","position":13,"is_corresponding":false},{"id":1138368,"name":"Nathella Pavan Kumar","orcid":"0000-0003-2969-2621","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T01:16:23.381203Z","pmid":"38005840","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}