{"doi":"10.3390/v14061149","title":"Adequacy of Hemodialysis Serves as an Independent Predictor of Humoral Response to ChAdOx1 Prime-Boost Vaccination in Hemodialysis Patients","abstract":"Background: Immune response assessed by the quantification of neutralizing antibodies (nAbs) and predictors associated with immunogenicity after the prime-boost ChAdOx1 (Oxford−AstraZeneca) COVID-19 vaccine in hemodialysis (HD) patients remains unclear. Methods: This prospective study enrolled 174 HD patients and 67 healthy subjects to evaluate antibodies against the spike protein 1 and receptor-binding domain of severe acute respiratory syndrome coronavirus type 2 after prime-booster vaccination, by using enzyme-linked immunosorbent assay and applied spline-based generalized additive model regression analysis to predict 50% neutralization titer (NT50). The correlation between HD parameters and NT50 was analyzed. Results: NT50 was lower in HD patients compared with healthy controls after the prime-boost dose (p < 0.001). The geometric mean titer ratios were higher in first-dose seronegative than in the seropositive subgroup in HD patients and healthy controls (6.96 vs. 2.36, p = 0.002, and 9.28 vs. 1.26, p = 0.011, respectively). After two doses of ChAdOx1, one-way ANOVA showed that Ca × P was positively associated with NT50 (p trend = 0.043) and multiple linear regression showed the similar results (p = 0.021). Kt/V (a quantification of dialysis adequacy) (OR = 20.295, p = 0.005) could independently predict seroconversion (NT50 ≥ 35.13 IU/mL). Conclusion: Adequacy of hemodialysis could independently predict seroconversion in HD subjects vaccinated with prime-boost doses of ChAdOx1.","journal":"Viruses","year":2022,"id":291128,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9594,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":713312,"name":"Kuan‐Ting Liu","orcid":"0000-0002-1355-5019","position":1,"is_corresponding":false},{"id":559167,"name":"Shin‐Ru Shih","orcid":"0000-0003-4874-401X","position":2,"is_corresponding":false},{"id":946371,"name":"Jung-Jr Ye","orcid":"0000-0003-3657-6901","position":3,"is_corresponding":false},{"id":946806,"name":"Yih-Ting Chen","orcid":null,"position":4,"is_corresponding":false},{"id":860288,"name":"Cheng-Kai Hsu","orcid":"0000-0002-6812-526X","position":5,"is_corresponding":false},{"id":860289,"name":"Heng‐Chih Pan","orcid":"0000-0001-5782-7138","position":6,"is_corresponding":false},{"id":946372,"name":"Heng-Jung Hsu","orcid":"0000-0002-6283-6239","position":7,"is_corresponding":false},{"id":946373,"name":"Chiao‐Yin Sun","orcid":"0000-0001-7438-8042","position":8,"is_corresponding":false},{"id":946374,"name":"Chin‐Chan Lee","orcid":"0000-0003-1165-095X","position":9,"is_corresponding":false},{"id":946375,"name":"Chun‐Ying Wu","orcid":"0000-0001-5053-1801","position":10,"is_corresponding":false},{"id":459628,"name":"Chi‐Chun Lai","orcid":"0000-0001-9547-7212","position":11,"is_corresponding":false},{"id":860666,"name":"I‐Wen Wu","orcid":"0000-0001-8535-3582","position":12,"is_corresponding":false},{"id":946370,"name":"Chun‐Yu Chen","orcid":"0000-0001-6054-1974","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T00:30:34.502076Z","pmid":"35746621","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}