{"doi":"10.3390/v13101909","title":"Interaction between NS1 and Cellular MAVS Contributes to NS1 Mitochondria Targeting","abstract":"Influenza A virus nonstructural protein 1 (NS1) plays an important role in evading host innate immunity. NS1 inhibits interferon (IFN) responses via multiple mechanisms, including sequestering dsRNA and suppressing retinoic acid-inducible gene I (RIG-I) signaling by interacting with RIG-I and tripartite motif-containing protein 25 (TRIM25). In the current study, we demonstrated the mitochondrial localization of NS1 at the early stage of influenza virus infection. Since NS1 does not contain mitochondria-targeting signals, we suspected that there is an association between the NS1 and mitochondrial proteins. This hypothesis was tested by demonstrating the interaction of NS1 with mitochondrial antiviral-signaling protein (MAVS) in a RIG-I-independent manner. Importantly, the association with MAVS facilitated the mitochondrial localization of NS1 and thereby significantly impeded MAVS-mediated Type I IFN production.","journal":"Viruses","year":2021,"id":196611,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.961,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":769845,"name":"Chih-Ying Kuan","orcid":null,"position":1,"is_corresponding":false},{"id":769846,"name":"Masaki Mibayashi","orcid":null,"position":2,"is_corresponding":false},{"id":769250,"name":"Chi-Jene Chen","orcid":"0000-0002-2292-7769","position":3,"is_corresponding":false},{"id":234854,"name":"Peter Palese","orcid":"0000-0002-0337-5823","position":4,"is_corresponding":false},{"id":103720,"name":"Randy A. Albrecht","orcid":"0000-0003-4008-503X","position":5,"is_corresponding":false},{"id":769251,"name":"Wei‐Li Hsu","orcid":"0000-0002-1392-163X","position":6,"is_corresponding":false},{"id":769844,"name":"Yeu‐Yang Tseng","orcid":null,"position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-18T23:50:15.704473Z","pmid":"34696339","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}