{"doi":"10.3390/v13071262","title":"Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone","abstract":"<jats:p>West Nile virus disease (WND) is an arthropod-borne zoonosis responsible for nonspecific fever or severe encephalitis. The pathogen is West Nile virus belonging to the genus Flavivirus, family Flaviviridae. Every year, thousands of cases were reported, which poses significant public health risk. Here, we constructed a West Nile virus chimera, ChiVax-WN01, by replacing the prMΔE gene of JEV SA14-14-2 with that of the West Nile virus NY99. The ChiVax-WN01 chimera showed clear, different characters compared with that of JEV SA14-14-2 and WNV NY99 strain. An animal study indicated that the ChiVax-WN01 chimera presented moderate safety and immunogenicity for 4-week female BALB/c mice.</jats:p>","journal":"Viruses","year":2021,"id":25466,"datarank":0.49366984431258,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.22490592392837175,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.22490592392837175,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":5,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":149755,"name":"Xianyong Meng","orcid":null,"position":1,"is_corresponding":false},{"id":149756,"name":"Zhiguang Ren","orcid":null,"position":2,"is_corresponding":false},{"id":149757,"name":"Entao Li","orcid":null,"position":3,"is_corresponding":false},{"id":149758,"name":"Feihu Yan","orcid":null,"position":4,"is_corresponding":false},{"id":110429,"name":"Jing Liu","orcid":"0000-0002-2832-1952","position":5,"is_corresponding":false},{"id":4679,"name":"Ying Zhang","orcid":"0000-0002-9638-9633","position":6,"is_corresponding":false},{"id":149760,"name":"Zhanding Cui","orcid":null,"position":7,"is_corresponding":false},{"id":149761,"name":"Yuetao Li","orcid":null,"position":8,"is_corresponding":false},{"id":149762,"name":"Hongli Jin","orcid":null,"position":9,"is_corresponding":false},{"id":107096,"name":"Zengguo Cao","orcid":null,"position":10,"is_corresponding":false},{"id":149763,"name":"Le Yi","orcid":null,"position":11,"is_corresponding":false},{"id":149764,"name":"Pei Huang","orcid":null,"position":12,"is_corresponding":false},{"id":149765,"name":"Hang Chi","orcid":null,"position":13,"is_corresponding":false},{"id":107098,"name":"Hualei Wang","orcid":"0000-0001-6961-1991","position":14,"is_corresponding":false},{"id":149766,"name":"Weiyang Sun","orcid":null,"position":15,"is_corresponding":false},{"id":149767,"name":"Tiecheng Wang","orcid":"0000-0002-5037-4911","position":16,"is_corresponding":false},{"id":149768,"name":"Yuwei Gao","orcid":null,"position":17,"is_corresponding":false},{"id":149769,"name":"Yongkun Zhao","orcid":null,"position":18,"is_corresponding":false},{"id":149770,"name":"Songtao Yang","orcid":null,"position":19,"is_corresponding":false},{"id":149771,"name":"Xianzhu Xia","orcid":null,"position":20,"is_corresponding":false},{"id":149754,"name":"Guohua Li","orcid":"0000-0002-9073-3907","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34209472","pmcid":"PMC8309971","openalex_id":"https://openalex.org/W3176950674","authors":[],"funders":[{"funder_name":"Fundação para a Ciência e a Tecnologia, I.P.","grant_id":"PTDC/CCI-BIO/29266/2017","title":"Deep Drug Discovery and Deployment"}],"total_grants":1,"fwci":0.7897,"citation_percentile":0.74285465,"influential_citations":0,"citation_trend":[{"year":2023,"count":3},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1999-4915/13/7/1262/pdf?version=1626232129","host_type":"journal"},{"url":"https://www.mdpi.com/1999-4915/13/7/1262/pdf?version=1626232129","host_type":"GOLD"},{"url":"https://www.mdpi.com/1999-4915/13/7/1262/pdf?version=1626232129","host_type":"publisher"},{"url":"https://www.mdpi.com/1999-4915/13/7/1262/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/v13071262","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34209472","host_type":"repository"},{"url":"https://doaj.org/article/a15c54d2b61f4b448e1fb36c9c94cf0d","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/v13071262","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8309971","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8309971","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8309971?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3390/v13071262","host_type":""}],"fields_of_study":["Mosquito-borne diseases and control","Viral Infections and Vectors","Insect symbiosis and bacterial influences","Medicine","Biology","Environmental Science","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Cell Line","Chimera","Cricetinae","Encephalitis Virus, Japanese","Female","Mice","Mice, Inbred BALB C","Virulence","West Nile virus"],"mesh_terms":["Animals","Cell Line","Chimera","Encephalitis Virus, Japanese","Female","Cricetinae","Mice, Inbred BALB C","Virulence","West Nile virus","Mice"],"keywords":["Virology","Flaviviridae","Japanese encephalitis","Flavivirus","West Nile virus","Chimera (genetics)","Biology","Virus","Yellow fever","Encephalitis","Immunogenicity","Veterinary virology","Viral disease","Gene","Genetics","Immune system","Japanese encephalitis virus","Chimera","Encephalitis Virus, Japanese","Mice, Inbred BALB C","Virulence","Microbiology","QR1-502","Article","Cell Line","Mice","Cricetinae","Animals","Female"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T04:46:33.443510Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}