{"doi":"10.3390/v13061060","title":"Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation","abstract":"<jats:p>Flavivirus consists of a large number of arthropod-borne viruses, many of which cause life-threatening diseases in humans. A characteristic feature of flavivirus infection is to induce the rearrangement of intracellular membrane structure in the cytoplasm. This unique membranous structure called replication organelle is considered as a microenvironment that provides factors required for the activity of the flaviviral replication complex. The replication organelle serves as a place to coordinate viral RNA amplification, protein translation, and virion assembly and also to protect the viral replication complex from the cellular immune defense system. In this review, we summarize the current understanding of how the formation and function of membrane-associated flaviviral replication organelle are regulated by cellular factors.</jats:p>","journal":"Viruses","year":2021,"id":617703,"datarank":1.1653805885308746,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.5977521434431352,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.5977521434431352,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":42,"citers_with_citation_signal":27,"citers_with_endowment":27,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1593120,"name":"Youichi Suzuki","orcid":"0000-0003-3554-0755","position":1,"is_corresponding":false},{"id":1095175,"name":"Eiji Morita","orcid":"0000-0002-3781-6121","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Membrane-Associated Flavivirus Replication Complex—Its Organization and Regulation","abstract":"<jats:p>Flavivirus consists of a large number of arthropod-borne viruses, many of which cause life-threatening diseases in humans. A characteristic feature of flavivirus infection is to induce the rearrangement of intracellular membrane structure in the cytoplasm. This unique membranous structure called replication organelle is considered as a microenvironment that provides factors required for the activity of the flaviviral replication complex. The replication organelle serves as a place to coordinate viral RNA amplification, protein translation, and virion assembly and also to protect the viral replication complex from the cellular immune defense system. In this review, we summarize the current understanding of how the formation and function of membrane-associated flaviviral replication organelle are regulated by cellular factors.</jats:p>","is_dataset_classified":null,"base_score":3.784189633918261,"endowment":3.784189633918261,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34205058","pmcid":"PMC8228428","openalex_id":"https://openalex.org/W3169341467","authors":[],"funders":[{"funder_name":"Japan Society for the Promotion of Science","grant_id":"KAKENHI Grant Number JP19K07596","title":null}],"total_grants":1,"fwci":3.9882,"citation_percentile":0.9394765,"influential_citations":0,"citation_trend":[{"year":2021,"count":3},{"year":2022,"count":5},{"year":2023,"count":5},{"year":2024,"count":8},{"year":2025,"count":12},{"year":2026,"count":10}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1999-4915/13/6/1060/pdf?version=1622780932","host_type":"journal"},{"url":"https://www.mdpi.com/1999-4915/13/6/1060/pdf?version=1622780932","host_type":"publisher"},{"url":"https://www.mdpi.com/1999-4915/13/6/1060/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/v13061060","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34205058","host_type":"repository"},{"url":"https://hirosaki.repo.nii.ac.jp/records/2002291","host_type":"repository"},{"url":"https://doaj.org/article/137c22d276f545669f20ec710fba4482","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/v13061060","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8228428","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8228428","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8228428?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Mosquito-borne diseases and control","Viral Infections and Vectors","HIV Research and Treatment","Endoplasmic Reticulum","Flavivirus","Flavivirus Infections","Host-Pathogen Interactions","Humans","Intracellular Membranes","Protein Biosynthesis","RNA, Viral","Viral Nonstructural Proteins","Virus Replication"],"mesh_terms":["Endoplasmic Reticulum","Flavivirus","Humans","Intracellular Membranes","RNA, Viral","Protein Biosynthesis","Virus Replication","Viral Nonstructural Proteins","Flavivirus Infections","Host-Pathogen Interactions"],"keywords":["Flavivirus","Biology","Viral replication","Organelle","Cell biology","Cytoplasm","Virology","Replication (statistics)","Translation (biology)","Genetics","Virus","Gene","Endoplasmic reticulum","Replication Complex","Interferon-stimulated Genes","Cellular Factors","Replication Organelle","Membranous Microenvironment"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T02:25:39.027801Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}