{"doi":"10.3390/v12070726","title":"Human Endogenous Retrovirus K in Cancer: A Potential Biomarker and Immunotherapeutic Target","abstract":"In diseases where epigenetic mechanisms are changed, such as cancer, many genes show altered gene expression and inhibited genes become activated. Human endogenous retrovirus type K (HERV-K) expression is usually inhibited in normal cells from healthy adults. In tumor cells, however, HERV-K mRNA expression has been frequently documented to increase. Importantly, HERV-K-derived proteins can act as tumor-specific antigens, a class of neoantigens, and induce immune responses in different types of cancer. In this review, we describe the function of the HERV-K HML-2 subtype in carcinogenesis as biomarkers, and their potential as targets for cancer immunotherapy.","journal":"Viruses","year":2020,"id":56859,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":82,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9613,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":295823,"name":"Jez L. Marston","orcid":"0000-0001-9784-7926","position":1,"is_corresponding":false},{"id":295824,"name":"Miguel de Mulder Rougvie","orcid":"0000-0002-8026-7076","position":2,"is_corresponding":false},{"id":295825,"name":"Fábio E. Leal","orcid":"0000-0003-1986-3765","position":3,"is_corresponding":false},{"id":295826,"name":"Douglas F. Nixon","orcid":"0000-0002-2801-1786","position":4,"is_corresponding":false},{"id":36879,"name":"Marcelo A. Soares","orcid":"0000-0002-9013-2570","position":5,"is_corresponding":false},{"id":295822,"name":"Gislaine Curty","orcid":"0000-0002-9501-9374","position":0,"is_corresponding":true}],"reference_count":141,"raw_metadata":null,"created_at":"2026-07-18T21:06:09.605575Z","pmid":"32640516","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}