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Possible contributions of NanI to intestinal colonization are further supported by observations that the C. perfringens strains causing acute food poisoning in humans often lack the nanI gene, while other C. perfringens strains causing chronic intestinal infections in humans usually carry a nanI gene. Certain sialidase inhibitors have been shown to block NanI activity and reduce C. perfringens adherence to cultured enterocyte-like cells, opening the possibility that sialidase inhibitors could be useful therapeutics against C. perfringens intestinal infections. These initial in vitro observations should be tested for their in vivo significance using animal models of intestinal infections.</jats:p>","journal":"Toxins","year":2016,"id":688243,"datarank":0.6141516843333151,"base_score":4.0943445622221,"endowment":4.0943445622221,"self_citation_contribution":0.6141516843333151,"citation_network_contribution":0.0,"self_endowment_contribution":0.6141516843333151,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":59,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1797965,"name":"Francisco Uzal","orcid":null,"position":1,"is_corresponding":false},{"id":1797967,"name":"Bruce McClane","orcid":null,"position":2,"is_corresponding":false},{"id":775930,"name":"Jihong Li","orcid":"0000-0001-8500-6935","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Clostridium perfringens Sialidases: Potential Contributors to Intestinal Pathogenesis and Therapeutic Targets","abstract":"<jats:p>Clostridium perfringens is a major cause of histotoxic and intestinal infections of humans and other animals. This Gram-positive anaerobic bacterium can produce up to three sialidases named NanH, NanI, and NanJ. The role of sialidases in histotoxic infections, such as gas gangrene (clostridial myonecrosis), remains equivocal. However, recent in vitro studies suggest that NanI may contribute to intestinal virulence by upregulating production of some toxins associated with intestinal infection, increasing the binding and activity of some of those toxins, and enhancing adherence of C. perfringens to intestinal cells. Possible contributions of NanI to intestinal colonization are further supported by observations that the C. perfringens strains causing acute food poisoning in humans often lack the nanI gene, while other C. perfringens strains causing chronic intestinal infections in humans usually carry a nanI gene. Certain sialidase inhibitors have been shown to block NanI activity and reduce C. perfringens adherence to cultured enterocyte-like cells, opening the possibility that sialidase inhibitors could be useful therapeutics against C. perfringens intestinal infections. These initial in vitro observations should be tested for their in vivo significance using animal models of intestinal infections.</jats:p>","is_dataset_classified":null,"base_score":4.0943445622221,"endowment":4.0943445622221,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27869757","pmcid":"PMC5127137","openalex_id":"https://openalex.org/W2555852144","authors":[],"funders":[{"funder_name":"NIAID","grant_id":"R21 AI125796-1","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R21 AI125796","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R21AI125796-01","title":"Pathogenic Contributions of Clostridium perfringens NanI Sialidase"}],"total_grants":3,"fwci":3.0041,"citation_percentile":0.91171175,"influential_citations":0,"citation_trend":[{"year":2017,"count":6},{"year":2018,"count":4},{"year":2019,"count":4},{"year":2020,"count":9},{"year":2021,"count":8},{"year":2022,"count":5},{"year":2023,"count":7},{"year":2024,"count":8},{"year":2025,"count":5},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2072-6651/8/11/341/pdf?version=1479519831","host_type":"journal"},{"url":"https://www.mdpi.com/2072-6651/8/11/341/pdf?version=1479519831","host_type":"publisher"},{"url":"https://www.mdpi.com/2072-6651/8/11/341/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/toxins8110341","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27869757","host_type":"repository"},{"url":"https://d-scholarship.pitt.edu/40226/2/toxins-08-00341.pdf","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5127137","host_type":"repository"},{"url":"https://doaj.org/article/0b8c73dfea5440cf83bbe8c0ce5c2186","host_type":"repository"},{"url":"https://escholarship.org/uc/item/3r2392dt","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/toxins8110341","host_type":"repository"},{"url":"http://www.escholarship.org/uc/item/3r2392dt","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5127137","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5127137?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3390/toxins8110341","host_type":""},{"url":"https://doi.org/https://doi.org/10.3390/toxins8110341","host_type":""}],"fields_of_study":["Clostridium difficile and Clostridium perfringens research","Streptococcal Infections and Treatments","Botulinum Toxin and Related Neurological Disorders","0301 basic medicine","03 medical and health sciences","0303 health sciences"],"mesh_terms":["Animals","Bacterial Proteins","Bacterial Toxins","Clostridium Infections","Clostridium perfringens","Humans","Intestinal Diseases","Neuraminidase","Virulence","Gene Expression Regulation, Fungal"],"keywords":["Clostridium perfringens","Sialidase","Microbiology","Biology","Gas gangrene","Virulence","Clostridiaceae","Enterocyte","In vivo","Toxin","Bacteria","Small intestine","Neuraminidase","Enzyme","Biochemistry","Gene","toxins","Sialidases","Intestinal Infections","Sialidase Inhibitors","Bacterial Toxins","Review","Bacterial Proteins","Gene Expression Regulation, Fungal","2.2 Factors relating to the physical environment","Animals","Humans","Aetiology","Biomedical and Clinical Sciences","Prevention","R","Pharmacology and Pharmaceutical Sciences","Foodborne Illness","Intestinal Diseases","Emerging Infectious Diseases","Infectious Diseases","Fungal","Gene Expression Regulation","Medical Microbiology","Clostridium Infections","Medicine","Biochemistry and Cell Biology","Digestive Diseases","Infection"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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