{"doi":"10.3390/toxins2102411","title":"ADAM-15 Disintegrin-Like Domain Structure and Function","abstract":"<jats:p>The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals. Human ADAM-15 is the only member of the ADAM family with the integrin binding motif Arg-Gly-Asp (RGD) in its disintegrin-like domain. This motif is also found in most snake venom disintegrins and other disintegrin-like proteins. This unique RGD motif within ADAM-15 serves as an integrin ligand binding site, through which it plays a pivotal role in interacting with integrin receptors, a large family of heterodimeric transmembrane glycoproteins. This manuscript will present a review of the RGD-containing disintegrin-like domain structures and the structural features responsible for their activity as antagonists of integrin function in relation to the canonical RGD template.</jats:p>","journal":"Toxins","year":2010,"id":661678,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1727372,"name":"Mike Scully","orcid":null,"position":1,"is_corresponding":false},{"id":1727373,"name":"Vijay Kakkar","orcid":null,"position":2,"is_corresponding":false},{"id":1727374,"name":"Xinjie Lu","orcid":null,"position":3,"is_corresponding":false},{"id":245724,"name":"Dong Lu","orcid":"0000-0002-9919-6378","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"ADAM-15 Disintegrin-Like Domain Structure and Function","abstract":"<jats:p>The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals. Human ADAM-15 is the only member of the ADAM family with the integrin binding motif Arg-Gly-Asp (RGD) in its disintegrin-like domain. This motif is also found in most snake venom disintegrins and other disintegrin-like proteins. This unique RGD motif within ADAM-15 serves as an integrin ligand binding site, through which it plays a pivotal role in interacting with integrin receptors, a large family of heterodimeric transmembrane glycoproteins. This manuscript will present a review of the RGD-containing disintegrin-like domain structures and the structural features responsible for their activity as antagonists of integrin function in relation to the canonical RGD template.</jats:p>","is_dataset_classified":null,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22069559","pmcid":"PMC3153164","openalex_id":"https://openalex.org/W2120932517","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"unidentified","title":"unidentified"}],"total_grants":1,"fwci":0.2984,"citation_percentile":0.56993007,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2072-6651/2/10/2411/pdf?version=1287489229","host_type":"journal"},{"url":"https://www.mdpi.com/2072-6651/2/10/2411/pdf?version=1287489229","host_type":"publisher"},{"url":"https://www.mdpi.com/2072-6651/2/10/2411/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/toxins2102411","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22069559","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3153164","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.300","host_type":""},{"url":"https://doaj.org/article/161b7236ff8f4a3386fc13846bc08177","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/toxins2102411","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3153164","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3153164?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3390/toxins2102411","host_type":""}],"fields_of_study":["Cell Adhesion Molecules Research","Signaling Pathways in Disease","Biochemical and Structural Characterization","0301 basic medicine","0303 health sciences","03 medical and health sciences","ADAM Proteins","Animals","Atherosclerosis","Disintegrins","Humans","Integrins","Membrane Proteins","Neoplasms","Protein Structure, Tertiary"],"mesh_terms":["Animals","Humans","Membrane Proteins","Neoplasms","Integrins","Protein Structure, Tertiary","Disintegrins","Atherosclerosis","ADAM Proteins"],"keywords":["Disintegrin","RGD motif","Integrin","Metalloproteinase","Glycoprotein","Cell biology","Transmembrane protein","Structural motif","Cell adhesion","Chemistry","Biology","Receptor","Biochemistry","Molecular biology","Matrix metalloproteinase","Cell","Adam Protein","Snake Venom Toxin","Rgd-motif","Integrins","Disintegrins","R","Membrane Proteins","Review","Atherosclerosis","Protein Structure, Tertiary","ADAM Proteins","Neoplasms","Medicine","Animals","Humans"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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