{"doi":"10.3390/toxins14060376","title":"Validation of a Culturally Relevant Snakebite Envenomation Clinical Practice Guideline in Brazil","abstract":"Snakebite envenoming (SBE) is a neglected tropical disease with significant global morbidity and mortality. Even when antivenom is available in low-resource areas, health workers do not receive adequate training to manage SBEs. This study aims to develop and validate a clinical practice guideline (CPG) for SBE management across Brazil. A panel of expert judges with academic and/or technical expertise in SBE management performed content validation. The content validity index (CVI) score was 90% for CPG objectives, 89% for structure and presentation and 92% for relevance and classified the CPG as valid. A semantic validation was performed by analyzing focus group discussions with doctors and nurses from three municipalities of the Brazilian Amazon, after a 5-day meeting during which the CPG was presented. Two central themes emerged: knowledge acquired during the meeting and recommendations for improving the CPG. Based on these results, the CPG was revised into a final version. This study presents the successful development and validation process of a CPG for SBE management, which is targeted to a specific low-resource, high-burden setting. This development and validation process can be adapted to other settings and/or other neglected tropical diseases.","journal":"Toxins","year":2022,"id":253499,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9636,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":897536,"name":"Altair Seabra de Farias","orcid":"0000-0003-1921-4888","position":1,"is_corresponding":false},{"id":899431,"name":"João Arthur Alcântara","orcid":"0000-0001-7765-7391","position":2,"is_corresponding":false},{"id":899432,"name":"Vinícius Azevedo Machado","orcid":"0000-0003-1189-2625","position":3,"is_corresponding":false},{"id":897538,"name":"Felipe Murta","orcid":"0000-0003-4414-3989","position":4,"is_corresponding":false},{"id":3925,"name":"Fernando Almeida-Val","orcid":"0000-0001-9995-0249","position":5,"is_corresponding":false},{"id":899433,"name":"Joseir Saturnino Cristino","orcid":"0000-0003-3225-2723","position":6,"is_corresponding":false},{"id":900093,"name":"Alícia Cacau Santos","orcid":null,"position":7,"is_corresponding":false},{"id":900094,"name":"Mena Ferreira","orcid":null,"position":8,"is_corresponding":false},{"id":899434,"name":"Leonardo Lincoln Gomes Marques","orcid":"0000-0002-6739-2315","position":9,"is_corresponding":false},{"id":900095,"name":"Yasmim Vieira Rocha","orcid":null,"position":10,"is_corresponding":false},{"id":897540,"name":"André Sachett","orcid":"0000-0001-6078-4941","position":11,"is_corresponding":false},{"id":899435,"name":"Mailma Costa de Almeida","orcid":"0000-0002-7412-0721","position":12,"is_corresponding":false},{"id":900096,"name":"Aline Alencar","orcid":null,"position":13,"is_corresponding":false},{"id":900097,"name":"Lisele Brasileiro","orcid":null,"position":14,"is_corresponding":false},{"id":899436,"name":"Érica da Silva Carvalho","orcid":"0000-0003-2528-2545","position":15,"is_corresponding":false},{"id":899437,"name":"Pedro Ferreira Bisneto","orcid":"0000-0002-2387-3002","position":16,"is_corresponding":false},{"id":3855,"name":"Marcus V. G. de Lacerda","orcid":"0000-0003-3374-9985","position":17,"is_corresponding":false},{"id":897535,"name":"Anna Tupetz","orcid":"0000-0003-4216-9253","position":18,"is_corresponding":false},{"id":447225,"name":"Catherine A. Staton","orcid":"0000-0002-6468-2894","position":19,"is_corresponding":false},{"id":28624,"name":"João Ricardo Nickenig Vissoci","orcid":"0000-0001-7276-0402","position":20,"is_corresponding":false},{"id":899438,"name":"Elizabeth Teixeira","orcid":"0000-0002-5401-8105","position":21,"is_corresponding":false},{"id":355915,"name":"Charles J. 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