{"doi":"10.3390/pharmaceutics16091228","title":"Nanotechnology in Advancing Chimeric Antigen Receptor T Cell Therapy for Cancer Treatment","abstract":"Chimeric antigen receptor (CAR) T cell therapy has emerged as a groundbreaking treatment for hematological cancers, yet it faces significant hurdles, particularly regarding its efficacy in solid tumors and concerning associated adverse effects. This review provides a comprehensive analysis of the advancements and ongoing challenges in CAR-T therapy. We highlight the transformative potential of nanotechnology in enhancing CAR-T therapy by improving targeting precision, modulating the immune-suppressive tumor microenvironment, and overcoming physical barriers. Nanotechnology facilitates efficient CAR gene delivery into T cells, boosting transfection efficiency and potentially reducing therapy costs. Moreover, nanotechnology offers innovative solutions to mitigate cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Cutting-edge nanotechnology platforms for real-time monitoring of CAR-T cell activity and cytokine release are also discussed. By integrating these advancements, we aim to provide valuable insights and pave the way for the next generation of CAR-T cell therapies to overcome current limitations and enhance therapeutic outcomes.","journal":"Pharmaceutics","year":2024,"id":431768,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1236033,"name":"Nur Mita","orcid":"0000-0002-6355-6888","position":1,"is_corresponding":false},{"id":799083,"name":"Lang Zhou","orcid":"0000-0002-4316-1192","position":2,"is_corresponding":false},{"id":1113545,"name":"Siqi Wu","orcid":"0000-0001-8156-5596","position":3,"is_corresponding":false},{"id":659881,"name":"Zongliang Yue","orcid":"0000-0001-8290-123X","position":4,"is_corresponding":false},{"id":1029220,"name":"R. Jayachandra Babu","orcid":"0000-0003-0337-2291","position":5,"is_corresponding":false},{"id":356797,"name":"Pengyu Chen","orcid":"0000-0003-3380-872X","position":6,"is_corresponding":false},{"id":693408,"name":"Xuejia Kang","orcid":"0000-0003-4336-2098","position":0,"is_corresponding":true}],"reference_count":203,"raw_metadata":null,"created_at":"2026-07-19T01:59:30.747263Z","pmid":"39339264","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}