{"doi":"10.3390/ph18091413","title":"Obesity-Related Cancers in Relation to Use of Statins and Testosterone Replacement Therapy Among Older Women: SEER-Medicare 2007–2015","abstract":"Background/Objectives: The associations of statins and testosterone replacement therapy (TTh) with the risk of obesity-related cancers (ORC, breast [BrCa], colorectal [CRC], ovarian, and endometrial cancers) in older women remain poorly understood. This study examined the associations between the use of statins and TTh with risk of ORC and its cancer-specific sites in women aged 65 years and older. Methods: A retrospective cohort study was conducted using 2007–2015 SEER-Medicare data, including 142,772 women aged ≥ 65 years. We identified 52,086 women with incident ORC (BrCa [n = 32,707], CRC [n = 11,070], ovarian [n = 2601], and endometrial [n = 5708] cancers). The primary exposures were use of statins and TTh. Weighted multivariable time-dependent Cox proportional hazards and models were conducted to estimate hazard ratios (HRs) of incident ORC. Results: We found an inverse association of statins with incident [HR, 0.76; 95% CI: 0.74, 0.78], high-grade [HR, 0.75; 95% CI: 0.72, 0.78], and advanced-stage [HR, 0.91; 95% CI: 0.88, 0.95] ORC. Concurrent use of statins and TTh was associated with a reduced incidence of ORC and high-grade ORC. Similar associations were observed with BrCa. Statins were inversely associated with high-grade ovarian cancer and endometrial cancer (incident, high-grade, and advanced-stage). Conclusions: Use of statins was inversely associated with ORC, BrCa, and endometrial cancer (high-grade and advanced-stage) and high-grade ovarian cancer in older women. Concurrent use of statins and TTh was inversely associated with ORC and BrCa and their high-grade disease. Future prospective studies are needed to substantiate these findings, especially with a focus to examine time– and dose–response associations and to identify underlying biological mechanisms through which statins and TTh influence incidence of ORC.","journal":"Pharmaceuticals","year":2025,"id":547007,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":915187,"name":"Shannon S. Wu","orcid":"0000-0002-0809-9143","position":1,"is_corresponding":false},{"id":1439455,"name":"Diane Saab","orcid":null,"position":2,"is_corresponding":false},{"id":955943,"name":"Biai Dominique Elmir Digbeu","orcid":"0000-0001-8741-9506","position":3,"is_corresponding":false},{"id":1341138,"name":"Omer Abdelgadir","orcid":"0009-0002-6104-0156","position":4,"is_corresponding":false},{"id":1050594,"name":"Jesús Gibran Hernández‐Pérez","orcid":"0000-0002-7637-4127","position":5,"is_corresponding":false},{"id":919610,"name":"Luisa Torres‐Sánchez","orcid":"0000-0002-2902-9881","position":6,"is_corresponding":false},{"id":1077990,"name":"Tammy Leonard","orcid":"0000-0002-8621-9358","position":7,"is_corresponding":false},{"id":443950,"name":"Miguel Ángel Cano","orcid":"0000-0002-9847-1358","position":8,"is_corresponding":false},{"id":339830,"name":"Yong‐Fang Kuo","orcid":"0000-0003-1927-0927","position":9,"is_corresponding":false},{"id":370877,"name":"Alejandro Villasante‐Tezanos","orcid":"0000-0001-5108-8637","position":10,"is_corresponding":false},{"id":73780,"name":"David S. López","orcid":"0000-0002-2321-0372","position":11,"is_corresponding":false},{"id":1435302,"name":"M. Hussain","orcid":"0009-0009-2312-8449","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:53:36.567932Z","pmid":"41011280","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}