{"doi":"10.3390/ph16050757","title":"MKX-AS1 Gene Expression Associated with Variation in Drug Response to Oxaliplatin and Clinical Outcomes in Colorectal Cancer Patients","abstract":"Oxaliplatin (OXAL) is a commonly used chemotherapy for treating colorectal cancer (CRC). A recent genome wide association study (GWAS) showed that a genetic variant (rs11006706) in the lncRNA gene MKX-AS1 and partnered sense gene MKX could impact the response of genetically varied cell lines to OXAL treatment. This study found that the expression levels of MKX-AS1 and MKX in lymphocytes (LCLs) and CRC cell lines differed between the rs11006706 genotypes, indicating that this gene pair could play a role in OXAL response. Further analysis of patient survival data from the Cancer Genome Atlas (TCGA) and other sources showed that patients with high MKX-AS1 expression status had significantly worse overall survival (HR = 3.2; 95%CI = (1.17–9); p = 0.024) compared to cases with low MKX-AS1 expression status. Alternatively, high MKX expression status had significantly better overall survival (HR = 0.22; 95%CI = (0.07–0.7); p = 0.01) compared to cases with low MKX expression status. These results suggest an association between MKX-AS1 and MKX expression status that could be useful as a prognostic marker of response to OXAL and potential patient outcomes in CRC.","journal":"Pharmaceuticals","year":2023,"id":387516,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9445,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":606084,"name":"George W. Small","orcid":null,"position":1,"is_corresponding":false},{"id":576189,"name":"Adrian J. Green","orcid":"0000-0001-9429-1838","position":2,"is_corresponding":false},{"id":12245,"name":"Farida S. Akhtari","orcid":"0000-0002-1089-4488","position":3,"is_corresponding":false},{"id":12629,"name":"Alison A. Motsinger‐Reif","orcid":"0000-0003-1346-2493","position":4,"is_corresponding":false},{"id":773894,"name":"Júlia C.F. Quintanilha","orcid":"0000-0001-6908-4474","position":5,"is_corresponding":false},{"id":461234,"name":"Tammy M. Havener","orcid":"0000-0002-4613-0498","position":6,"is_corresponding":false},{"id":409229,"name":"David M. Reif","orcid":"0000-0001-7815-6767","position":7,"is_corresponding":false},{"id":32979,"name":"Howard L. McLeod","orcid":"0000-0002-9004-9232","position":8,"is_corresponding":false},{"id":591984,"name":"Tim Wiltshire","orcid":"0000-0001-5960-4034","position":9,"is_corresponding":false},{"id":1104002,"name":"Ricardo González","orcid":"0000-0002-2549-8138","position":0,"is_corresponding":true}],"reference_count":92,"raw_metadata":null,"created_at":"2026-07-19T01:18:08.845494Z","pmid":"37242540","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}