{"doi":"10.3390/ph13120434","title":"Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study","abstract":"The purpose of this pilot study was to investigate the feasibility of a perfusion catheter to deliver liquid paclitaxel into arterial segments. A clinically relevant rabbit ilio-femoral injury model was utilized to determine the impact of liquid paclitaxel delivered locally into the vessel wall using a perfusion catheter at 1 h to 14 days. Treatment by two clinically available forms of liquid paclitaxel, a solvent-based (sb) versus an albumin-bound (nab), along with a control (uncoated balloons), were investigated. Pharmacokinetic results demonstrated an increase in the retention of the sb-paclitaxel versus the nab-paclitaxel at 1 h; however, no other differences were observed at days one, three, and seven. Histological findings at 14 days showed significantly less neointimal area in the sb-paclitaxel treated arteries as compared with the nab-paclitaxel and the uncoated balloon-treated arteries. Additionally, percent area stenosis was significantly less in the sb-paclitaxel group. These results support the concept of local liquid delivery of paclitaxel into the arterial segments.","journal":"Pharmaceuticals","year":2020,"id":111377,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9606,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":528742,"name":"Kathryn Cooper","orcid":"0000-0002-2569-9693","position":1,"is_corresponding":false},{"id":529354,"name":"Clifton Huett","orcid":null,"position":2,"is_corresponding":false},{"id":529355,"name":"Alyssa Lloret","orcid":null,"position":3,"is_corresponding":false},{"id":529356,"name":"Estefanny Villar-Matamoros","orcid":null,"position":4,"is_corresponding":false},{"id":529357,"name":"Lauren Stokes","orcid":null,"position":5,"is_corresponding":false},{"id":419734,"name":"Uwe Christians","orcid":"0000-0001-7297-147X","position":6,"is_corresponding":false},{"id":529358,"name":"Michele A. Schuler","orcid":null,"position":7,"is_corresponding":false},{"id":419737,"name":"Saami K. Yazdani","orcid":"0000-0002-9719-6382","position":8,"is_corresponding":false},{"id":419733,"name":"Claire V. Cawthon","orcid":"0000-0002-9120-5479","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-18T23:13:05.597252Z","pmid":"33260517","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}