{"doi":"10.3390/pathogens13100877","title":"Administration of rIL-33 Restores Altered mDC/pDC Ratio, MDSC Frequency, and Th-17/Treg Ratio during Experimental Cerebral Malaria","abstract":"The onset of malaria causes the induction of various inflammatory markers in the host's body, which in turn affect the body's homeostasis and create several cerebral complications. Polarization of myeloid-derived suppressor cells (MDSCs) from the classically activated M1 to alternatively activated M2 phenotype increases the secretion of pro-inflammatory molecules. Treatment with recombinant IL-33 (rIL-33) not only alters this MDSC's polarization but also targets the glycolysis pathway of the metabolism in MDSCs, rendering them less immunosuppressive. Along with that, the Helper T-cells subset 17 (Th17)/T regulatory cells (Tregs) ratio is skewed towards Th17, which increases inflammation by producing more IL-17. However, treating with rIL-33 also helps to restore this ratio, which brings back homeostasis. During malaria infection, there is an upregulation of IL-12 production from dendritic cells along with a distorted myeloid dendritic cells (mDC)/plasmacytoid dendritic cells (pDC) ratio towards mDCs promoting inflammation. Administering rIL-33 will also subvert this IL-12 production and increase the population of pDC in the host's immune system during malaria infection, thus restoring mDC/pDC to homeostasis. Therefore, treatment with rIL-33 to reduce the pro-inflammatory signatures and maintenance of immune homeostasis along with the increase in survivability could be a potential therapeutic approach for cerebral malaria.","journal":"Pathogens","year":2024,"id":460199,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9444,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1288313,"name":"Pronabesh Ghosh","orcid":null,"position":1,"is_corresponding":false},{"id":1287701,"name":"Soubhik Ghosh","orcid":"0000-0002-1977-6787","position":2,"is_corresponding":false},{"id":1287702,"name":"Anirban Sengupta","orcid":"0000-0001-5385-0883","position":3,"is_corresponding":false},{"id":1288314,"name":"Samrat Sarkar","orcid":null,"position":4,"is_corresponding":false},{"id":1287703,"name":"Rimbik Chatterjee","orcid":"0009-0000-4190-4258","position":5,"is_corresponding":false},{"id":1287704,"name":"Atreyee Saha","orcid":"0009-0008-2104-7736","position":6,"is_corresponding":false},{"id":1288315,"name":"Sriparna Bawali","orcid":null,"position":7,"is_corresponding":false},{"id":1288316,"name":"Abhishek Choudhury","orcid":null,"position":8,"is_corresponding":false},{"id":1288317,"name":"Altamas Hossain Daptary","orcid":null,"position":9,"is_corresponding":false},{"id":1288318,"name":"Anwesha Gangopadhyay","orcid":null,"position":10,"is_corresponding":false},{"id":776154,"name":"Tarun Keswani","orcid":"0000-0002-0307-692X","position":11,"is_corresponding":false},{"id":1287705,"name":"Arindam Bhattacharyya","orcid":"0000-0002-0086-8219","position":12,"is_corresponding":false},{"id":1287700,"name":"Saikat Mukherjee","orcid":"0009-0007-3980-0485","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T02:04:03.568045Z","pmid":"39452748","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}