{"doi":"10.3390/pathogens10091092","title":"Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector","abstract":"<jats:p>Vesicular stomatitis virus (VSV), which belongs to the Vesiculovirus genus of the family Rhabdoviridae, is a well studied livestock pathogen and prototypic non-segmented, negative-sense RNA virus. Although VSV is responsible for causing economically significant outbreaks of vesicular stomatitis in cattle, horses, and swine, the virus also represents a valuable research tool for molecular biologists and virologists. Indeed, the establishment of a reverse genetics system for the recovery of infectious VSV from cDNA transformed the utility of this virus and paved the way for its use as a vaccine vector. A highly effective VSV-based vaccine against Ebola virus recently received clinical approval, and many other VSV-based vaccines have been developed, particularly for high-consequence viruses. This review seeks to provide a holistic but concise overview of VSV, covering the virus’s ascension from perennial agricultural scourge to promising medical countermeasure, with a particular focus on vaccines.</jats:p>","journal":"Pathogens","year":2021,"id":602384,"datarank":0.6698862177981877,"base_score":4.465908118654584,"endowment":4.465908118654584,"self_citation_contribution":0.6698862177981877,"citation_network_contribution":0.0,"self_endowment_contribution":0.6698862177981877,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":86,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1073795,"name":"Wenguang Cao","orcid":"0000-0003-4715-4296","position":1,"is_corresponding":false},{"id":1544841,"name":"Abdjeleel Salawudeen","orcid":null,"position":2,"is_corresponding":false},{"id":1093017,"name":"Wenjun Zhu","orcid":null,"position":3,"is_corresponding":false},{"id":1544842,"name":"Karla Emeterio","orcid":null,"position":4,"is_corresponding":false},{"id":294451,"name":"David Safronetz","orcid":"0000-0002-9024-728X","position":5,"is_corresponding":false},{"id":1073797,"name":"Logan Banadyga","orcid":"0000-0001-8390-2648","position":6,"is_corresponding":false},{"id":295772,"name":"Guodong Liu","orcid":"0000-0003-1922-2538","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector","abstract":"<jats:p>Vesicular stomatitis virus (VSV), which belongs to the Vesiculovirus genus of the family Rhabdoviridae, is a well studied livestock pathogen and prototypic non-segmented, negative-sense RNA virus. 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